期刊文献+

维生素D2对高龄女性血清25-羟基维生素D的影响 被引量:1

Influence of intramuscular injection of vitamin D2 on serum 25 -hydroxyvitamin D in aged women
收藏 分享 导出
摘要 目的 了解肌内注射维生素D2对高龄女性血清25-羟基维生素D的影响。方法 将40例高龄女性随机分为试验组20例和对照组20例。试验组在坚持晒太阳的基础上,连续3个月肌内注射维生素D2个60万U;对照组仅坚持晒太阳。所有高龄女性在治疗前和治疗后1~8个月,每月测1次血清25-羟基维生素D和血钙,比较2组高龄女性的血清25-羟基维生素D和血钙的差异。结果 试验组高龄女性在治疗后第3个月血清25-羟基维生素D水平为(19.76±3.28)ng·m L-1,对照组为(16.37±3.01)ng·m L-1,差异有统计学意义(P〈0.01),但在其他时间2组差异均无统计学意义(均P〉0.05)。2组高龄女性患者治疗期间血钙之间的差异均无统计学意义(均P〉0.05)。结论 连续肌内注射3次维生素D2,可提高高龄女性血清25-羟基维生素D水平,且对血钙水平无影响。 Objective To evaluate the influence of intramuscular injec- tion of vitamin D2 on serum 25 - hydroxyvitamin D in aged women. Methods A total of 40 aged women were randomly divided into treatment group and control group, each group 20 patients. Patients in treatment group were given vitamin D2 injection 6. 0 ×10^5 U every month, intramuscular injection, for 3 months. Control group was given sunshine treatment. The levels of serum 25 - hydroxyvitamin D and calcium were evaluated and compared before treatment and after 8 months treatment. Results After 3 months treatment, serum 25 - hydroxyvitamin D in treatment group and control group were ( 19.76 ± 3.28 ), (16.37 ± 3.01 ) ng·mL-1, with significant difference (P 〈 0. 01 ), and the levels of serum 25 - hydroxyvitamin D in other times had no significant difference ( all P 〉 0.05 ). There was no significant difference in serum calcium between treatment and control group during 9 months ( all P 〉 0. 05 ). Conclusion Vitamin D2 injection could be used to increase serum 25 -hydroxyvitamin D level, and it had no effect on serum calcium.
作者 杨其刚 钱素凤 边平达 寿张轩 陈锦平 YANG Qi - gang 1a, QIAN Su - feng 1b, BIAN Ping - da1b, SHOU Zhang - xuan1c, CHEN Jin - ping1b(1.a Department of Gastroenterology; b. Center for Diagnosis and Treatment of Osteoporosis ; ~ Department of Pharmaceutical Sciences, Zhejiang Provincial People' s Hospital & People' s Hospital of Hangzhou Medical College, Hangzhou 310024, China)
出处 《中国临床药理学杂志》 CSCD 北大核心 2018年第6期640-642,共3页 The Chinese Journal of Clinical Pharmacology
基金 浙江省医药卫生科技计划基金资助项目(2016ZDA002,2018KY222)
关键词 维生素D 血钙 老年女性 vitamin D calcium aged women
作者简介 杨其刚(1981-),男,主治医师,主要从事临床医疗工作;通信作者:边平达,主任医师 MP:13588369479 E-mail:bianpingda@hotmail.com
  • 相关文献

参考文献3

二级参考文献33

  • 1Holick MF. Vitamin D:Its role in cancer prevention and treatment[J].Progress in Biophysics and Molecular Biology,2006,(1):49-59.doi:10.1016/j.pbiomolbio.2006.02.014. 被引量:1
  • 2Holick MF. Vitamin D status:neasurement,interpretation,and clinical application[J].Annals of Epidemiology,2009.73-78. 被引量:1
  • 3Miller EH. Vitamin D insufficiency in male osteoporosis[J].Clinical Cornerstone,2006,(Suppl.3):S14-S19. 被引量:1
  • 4Lanske B,Razzaque MS. Vitamin D and aging:old concepts and new insights[J].Journal of Nutritional Biochemistry,2007.771-777. 被引量:1
  • 5Zittermann A,Gummert JF. Sun,vitamin D,and cardiovascular disease[J].Journal of Photochemistry and Photobiology B:Biology,2010.124-129. 被引量:1
  • 6Hollis BW. Circulating 25-Hydroxyvitamin D levels indicative of vitamin D sufficiency:implications for establishing a new effective dietary intake recommendation for vitamin D[J].Journal of Nutrition,2005.317-322. 被引量:1
  • 7Heaney RP. The Vitamin D requirement in health and disease[J].Journal of Steroid Biochemistry and Molecular Biology,2005.13-19. 被引量:1
  • 8Wolpowitz D,Gilchrest BA. The vitamin D questions:How much do you need and how should you get it[J].JAmAcad of Dermatol,2006.301-317. 被引量:1
  • 9Whiting SJ,Calvo MS. Dietary recommendations to meet both endocrine and autocrine needs of vitamin D[J].Journal of Steroid Biochemistry and Molecular Biology,2005.7-12. 被引量:1
  • 10TuohimaaP. Vitamin D and aging[J].Journal of Steroid Biochemistry and Molecular Biology,2009.78-84. 被引量:1

共引文献18

同被引文献2

引证文献1

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈