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穴位贴敷诱发的接触性皮炎对支气管哮喘患者哮喘控制水平及血清IFN-γ/IL-4的影响 被引量:4

Effect of Acupoint Application Induced Contact Dermatitis on Asthma Control and Serum IFN-γ/IL-4 in Asthmatic Patients
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摘要 目的探讨穴位贴敷诱发的接触性皮炎对支气管哮喘患者哮喘控制水平的影响及可能作用机制。方法选取2016年三伏天接受穴位贴敷治疗的支气管哮喘患者41例,根据穴位贴敷治疗后是否出现接触性皮炎分为接触性皮炎组、无接触性皮炎组。观察患者治疗结束后3个月(2016年11月)、6个月(2017年2月)时及前1年同时期(2015年11月及2016年2月)哮喘控制测试(ACT)评分,并于治疗前后检测患者血清γ干扰素(IFN-γ)和白细胞介素4(IL-4)含量,计算IFN-γ/IL-4。结果与本组2015年11月比较,两组患者2016年11月时ACT评分升高(P〈0.05);接触性皮炎组2017年2月ACT评分较本组2016年2月亦升高(P〈0.05)。接触性皮炎组治疗后与治疗前比较,IL-4含量下降(P〈0.05),而IFN-γ含量及IFN-γ/IL-4差异无统计学意义(P〉0.05)。无接触性皮炎组治疗前后IL-4、IFN-γ含量及IFN-γ/IL-4差异无统计学意义(P〉0.05)。结论穴位贴敷后出现接触性皮炎可提高支气管哮喘患者的哮喘控制水平,优于无接触性皮炎者,其机制可能与抑制炎症有关。 Objective To explore the effect of contact dermatitis induced by acupoint application on the asthma control level and its potential mechanism. Methods Forty-one patients with bronchial asthma treated with acupoint application in 2016 dog days were divided into contact dermatitis group and non-contact dermatitis group according to the contact dermatitis situation after acupoint application,observing the asthma control test(ACT) scores 3 months(November 2016) and 6 months(February 2017) after the end of treatment and in the same period of the previous year(November 2015 and February 2016). Serum interferon-γ(IFN-γ) and interleukin-4(IL-4) levels were measured before and after treatment to calculate IFN-γ/IL-4. Results Compared with that in the own group in November 2015,the ACT scores increased in both groups in November 2016(P〈0. 05); the ACT score in contact dermatitis group in February 2017 also increased compared with that in February 2016 in this group(P〈0. 05). In the contact dermatitis group,the IL-4 level decreased after treatment(P〈0. 05),but the IFN-γ level and IFN-γ/IL-4 had no significant difference(P〈0. 05) from those before treatment(P〈0. 05). There was no significant difference in the levels of IL-4,IFN-γ and IFN-γ/IL-4 before and after treatment in the non-contact dermatitis group(P〈0. 05). Conclusion Contact dermatitis after acupoint application can improve asthma control in patients with bronchial asthma,better than non-contact dermatitis. The mechanism may be related to the inhibition of inflammation.
作者 王会 王和生 刘兰英 秦铎 张聪 刘成勇 董杰 操海玲 彭博 WANG Hui1,2, WANG Hesheng2, LIU Lanying2, QIN Duo1, ZHANG Cong2, LIU Chengyong2, DONG Jie2, CAO Hailing1,2, PENG Bo1,2 ( 1. Nanjing University of Chinese Medicine, Nanjing, 210029; 2. Affiliated HoSpital of Nanjing University of Chinese Medicine)
出处 《中医杂志》 CSCD 北大核心 2018年第7期582-585,共4页 Journal of Traditional Chinese Medicine
基金 国家自然科学基金(81674065) 江苏省中医药局科技项目(YB2017026) 江苏省科技发展计划(BE2017771)
关键词 接触性皮炎 穴位贴敷 支气管哮喘 Γ干扰素 白细胞介素4 contact dermatitis acupoint application bronchial asthma interferon-γ interleukin-4
作者简介 通讯作者:warIghesheng2010@126.com
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