Objective To understand the clinical eradication therapy for Helicobacter pylori infection in children and analyze the causes. Methods H.pylori eradication therapy for 10 or 14 days was accepted by 301 cases of children, who were diagnosed with H.pyori infection, in the Children＇ s Hospital of Zhejiang University School of Medicine from January, 2012 to October, 2015. Finally, the eradication rate of H.pylori was judged. Results In initial treatment, the eradication rate of OAC program （omeprazole, amoxicillin and clarithromycin） was 42.3%, the eradication rate of non- OAC program was 56.7%, and there were statistically significant differences between the two groups （P〈 0.05）. The eradication rate of bismuth-based regimens was 50.0%, the eradication rate of standard triple therapy was 41.2%, and there were no statistically significant differences between the two groups （P〉0.05）. In the rescue treatment, the eradication rate of bismuth-based quadruple therapy was 58.3%, the eradication rate of triple therapy with furaxone was 55.0%, and there were no statistically significant differences between the two groups （P 〉 0.05）. Totally 119 strains of H. pylon were not resistant to amoxicillin, while the resistance rate to clarithromycin and metronidazole was 27.7% and 69.3%, respectively. Conclusion In this study, the clinical eradication rate in children with Hp infection fails to achieve the goal eradication rate of 80%. Drug sensitivity test is still the first choice for treatment of Helicobacter pylori infection in children.
Chinese Journal of Practical Pediatrics
drug sensitivity test