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胶红酵母胞外多糖的抗疲劳作用 预览 被引量:1

Antifatigue effect of extracellular polysaccharide from Rhodotorula mucilaginosa
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摘要 将小鼠随机分成正常对照组(生理盐水)、胶红酵母多糖高(100 mg/kg·bw)、中(50 mg/kg·bw)和低(25 mg/kg·bw)剂量组,连续灌胃10 d后,通过小鼠负重游泳实验,记录小鼠力竭游泳时间,并测定小鼠运动后血清中尿素氮(BUN)、血乳酸(BLA)和乳酸脱氢酶(LDH)的水平以及肝脏中的丙二醛(MDA)、超氧化物岐化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-Px)的水平,考察胶红酵母胞外多糖的抗疲劳作用。结果表明,胶红酵母胞外多糖可以极显著延长小鼠负重游泳时间(p〈0.01),负重游泳后与正常组相比,血清中BUN的含量显著降低(高剂量组p〈0.01,中、低剂量组p〈0.05),BLA的含量也显著降低(高剂量组p〈0.01,中剂量组p〈0.05),血清中LDH的活性明显提高(高剂量组p〈0.05),肝脏中MDA的含量显著下降(高、中、低剂量组p〈0.05),SOD活力显著提高(高剂量组p〈0.01,中剂量组p〈0.05),CAT活性极显著提高(高、中、低剂量组p〈0.01),GPH-Px活力显著提高(高剂量组p〈0.01,中、低剂量组p〈0.05)。说明胶红酵母胞外多糖具有抗疲劳的作用。 The mice were randomly divided into normal control group (physiological saline), Rhodotorula mucilaginosa polysaccharide high dose group (100 mg/kg·bw), medium dose group (50 mg/kg·bw), low dose group (25 mg/kg· bw), continuous intragastric administration after 10 days, the swimming time of mice was recorded by exhausted swimming test, and the level of serum urea nitrogen ( BUN ), blood lactate ( BLA ) and lactate dehydrogenase ( LDH ) levels and the determination of malondialdehyde in the liver ( MDA), superoxide dismutase ( SOD ), catalase (CAT) and glutathione peroxidase ( GSH-Px ). The aim was to investigate the antifatigue effect of extracellalar polysaccharide from Rhodotorula mucilaginosa. The results showed that extracellular polysaccharide could significantly prolong the swimming time of mice (p 〈 0.01 ). Compared with the normal group, serum BUN level decreased significantly(p 〈 0.01 for high dose group ,p 〈 0.05 for medium and low dose groups), BLA content also decreased significantly (p 〈 0.01 for high dose group,p 〈 0.05 for medium dose group), LDH activity was significantly increased(p 〈 0.05 for high dose group ) , the content of the MDA in liver decreased significantly (p 〈 0.05 for high, medimn and low dose groups), SOD activity increased significantly(p 〈 0.01 for high dose group ,p 〈 0.05 for middle dose group) , CAT activity was significantly increased (p 〈 0.01 for high, medium and low dose groups)and GPH-Px activity was significantly increased(p 〈 0.01 for high dose group,p 〈 0.05 for medium and low dose groups).Rhodotorula mucilaginosa extracellular polysaccharide had anti-fatigue effect.
作者 康雨芳 陈雪峰 常相娜 赵圆圆 KANG Yu-fang, CHEN Xue-feng, CHANG Xiang-na, ZHAO Yuan-yuan(School of Food and Biological Engineering, Shaanxi University of Science and Technology,Xi' an 710021, China)
出处 《食品工业科技》 CSCD 北大核心 2018年第9期301-305,共5页 Science and Technology of Food Industry
基金 西安市微生物药物工程实验室项目 陕西省重点研发计划项目(2017NY-146).
关键词 胶红酵母 胞外多糖 抗疲劳 Rhodotorula mucilaginosa extracellular polysaccharide antifatigue
作者简介 康雨芳(1993-),女,硕士研究生,研究方向:食品科学与工程,E—mail:15029573599@163.com。;通讯作者:陈雪峰(1964-),男,博士,教授,研究方向:食品功能成分、食品生物技术研究,E—mail:chenxf@sust.edu.cn.
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