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药用植物萜类化合物的生物合成与代谢调控研究进展 被引量:3

Research progress in terms of the biosynthesis and regulation of terpenoids from medicinal plants
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摘要 药用植物来源的萜类化合物是自然界中广泛存在的次级代谢产物,其结构与功能多样,具有抗癌、抗氧化、抗病毒等广泛的药理作用.本文以青蒿素、丹参酮、人参皂苷为例,总结了其代谢途径关键酶基因、转录调控、代谢工程、合成生物学、合成与转运等研究进展,并对今后的发展方向进行展望。 Terpenoids from medicinal plants are widespread secondary metabolites in nature and exist as multiple types with different structures that are crucial in plant growth and development. Moreover, terpenoids exert a broad range of biological activities, including antitumor, antioxidation, anti-viral, and so on. In this study, artemisinin, tanshinone, and ginsenoside were selected as three representative examples, and progress in terms of research on biosynthetic genes, transcriptional regulation, metabolic engineering, synthetic biology, biosynthesis and transport was summarized. Future prospects including functional genes excavation and regulation mechanism network of terpenoids were also discussed.
作者 时敏 王瑶 周伟 花强 开国银 SHI Min1,2, WANG Yao2, ZHOU Wei2, HUA Qiang1 ,KAI GuoYin2( 1 State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China ;2 College of Life and Environmental Sciences, Shanghai Normal University, Shanghai 200234, China)
出处 《中国科学:生命科学》 CSCD 北大核心 2018年第4期352-364,共13页 SCIENTIA SINICA Vitae
基金 国家自然科学基金(批准号:81522049,31270007,31571735,30900110)、上海市科委项目(批准号:17JC1404300,15430502700)和上海市曙光学者计划(批准号:16SG38)资助
关键词 药用植物 萜类化合物 次级代谢 生物合成 调控 medicinal plants, terpenoids, secondary metabolism, biosynthesis, regulation
作者简介 E-mail:qhua@ecust.edu.cn;E-mail:guoyinkai@yahoo.com
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