Based on the self-developed non-axisymmetrical endwall optimization design platform, a non-axisymmetric endwall design was carried out on a high-load low-pressure turbine annular cascade, and the total pressure loss, SKEH, and the combination of the two parameters were optimized for different targets. The objective function was studied and the influence of the lower wall seal chamber was considered when calculating. The results of the research show that the sealing volume has an important influence on the secondary flow development in the end zone. The end wall shape can optimize the outflow direction and outflow characteristics of sealed cold air, thus inhibiting the development of the channel vortex. Therefore, the non-axisymmetric end wall design should take into account the cavity effect. When SKEH alone is used as the optimization goal, the optimization focuses on the reduction of the secondary kinetic energy, which inhibits the formation of the outflow eddies of sealing, and can not effectively inhibit the generation and development of the branch of the pressure surface of horseshoe vortex.
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