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注意缺陷多动障碍儿童自发脑活动的多参数静息态功能磁共振研究

A multi-parameter resting-state functional magnetic resonance imaging study of brain intrinsic activity in attention deficit hyperactivity disorder children
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摘要 注意缺陷多动障碍(ADHD)儿童的大脑功能异常已经被广泛报道,但是其结果存在不一致性,且半球间功能连接相关研究较少。本研究纳入了45名首发未用药ADHD儿童和26名正常对照儿童,进行静息态功能磁共振扫描。采用局部一致性(Re Ho)、度中心性(DC)和镜像同伦功能连接(VMHC)三种测量指标对两组受试的静息态脑活动进行比较分析。发现与正常儿童相比,ADHD儿童Re Ho值和DC值在右侧额中回区域降低,且两者呈正相关;VMHC值在双侧枕叶降低,且该改变与Conners父母用量表焦虑得分呈负相关,与威斯康星卡片测验正确分类数呈正相关。本研究结果提示了ADHD儿童右侧额中回及双侧枕叶自发神经活动的异常。 A great number of studies have demonstrated functional abnormalities in children with attentiondeficit/hyperactivity disorder(ADHD), although conflicting results have also been reported. And few studies analyzed homotopic functional connectivity between hemispheres. In this study, resting-state functional magnetic resonance imaging(MRI) data were recorded from 45 medication-na?ve ADHD children and 26 healthy controls. The regional homogeneity(Re Ho), degree centrality(DC) and voxel-mirrored homotopic connectivity(VMHC) values were compared between the two groups to depict the intrinsic brain activities. We found that ADHD children exhibited significantly lower Re Ho and DC values in the right middle frontal gyrus and the two values correlated with each other; moreover, lower VMHC values were found in the bilateral occipital lobes of ADHD children, which was negatively related with anxiety scores of Conners' Parent Rating Scale(CPRS-R) and positively related with completed categories of Wisconsin Card Sorting Test(WCST). Our results might suggest that less spontaneous neuronal activities of the right middle frontal gyrus and the bilateral occipital lobes in ADHD children.
作者 周家秀 高映雪 卜暄 李海龙 梁艳 陈宏 王美豪 林飞飞 杨闯 黄晓琦 ZHOU Jiaxiu1, GAO Yingxue2, BU Xuan2, LI Hailong2, LIANG Yan3, CHEN Hong3, WANG Meihao4 LIN Feifei5, YANG Chuang3, HUANG Xiaoqi2 (1 Department of Psychology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R.China 2.Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, P.R.China3 Mental Health Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R.China 4Radiology Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R.China Radiology Department, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R.China)
出处 《生物医学工程学杂志》 CSCD 北大核心 2018年第3期415-420,共6页 Journal of Biomedical Engineering
基金 国家自然科学基金面上项目(81671669) 浙江省自然科学基金(LY14H090012) 深圳市未来产业专项资金(JCYJ20170413093358429) 四川省青年科技基金项目(2017JQ0001)
关键词 注意缺陷多动障碍 功能磁共振成像 局部一致性 度中心性 镜像同伦功能连接 attention-deficit/hyperactivity disorder functional magnetic resonance imaging regionalhomogeneity degree centrality voxel-mirrored homotopic connectivity
作者简介 通信作者:杨闯,Email:dryangchuang@163.com
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