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补肾填精益髓方联合西药治疗阿尔茨海默病临床研究

Clinical Study on Bushen Tianjing Yisui Prescription Combined with Western Medicine for Alzheimer's Disease
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摘要 目的:观察补肾填精益髓方联合西药治疗阿尔茨海默病(AD)的临床疗效。方法:将94例AD肾虚髓亏证患者按照随机数字表法分为治疗组和对照组各47例。治疗组以补肾填精益髓方与盐酸多奈哌齐片治疗,对照组予盐酸多奈哌齐片治疗。2组均治疗6月。比较2组的疗效,观察患者治疗前后的认知功能[阿尔茨海默病评定量表-认知部分(ADAS-cog)、严重障碍量表(SIB)]、行为能力[痴呆行为量表(BEHAVE-AD)、日常生活能力量表(ADL)]及负面情绪[汉密顿焦虑量表(HAMA)、康奈尔痴呆抑郁量表(CSDD)]等评分的变化情况。结果:治疗6月后,治疗组总有效率(93.62%)高于对照组(76.60%),差异有统计学意义(P〈0.05)。2组ADAS-cog评分均较治疗前降低,SIB评分则较治疗前升高,差异均有统计学意义(P〈0.05);治疗组ADAS-cog评分低于对照组(P〈0.05)。2组BEHAVE-AD评分、ADL评分、HAMA评分、CSDD评分均较治疗前降低,差异均有统计学意义(P〈0.01);治疗组4项分值均低于对照组(P〈0.01)。结论:补肾填精益髓方不仅可有效提高AD患者的认知功能和行为能力,还能减轻其焦虑抑郁等负面情绪,联合盐酸多奈哌齐片可作为临床治疗AD的方案。 Objective: To observe the clinical effect of Bushen Tianjing Yisui prescription combined with western medicine for Alzheimer's disease(AD). Methods: Divided 94 cases of AD patients with syndrome of kidney marrow deficiency into the treatment group and the control group according to random number table method,47 cases in each group. The treatment group received Bushen Tianjing Yisui prescription and donepezil hydrochloride tablets for treatment,while the control group received donepezil hydrochloride tablets. The treatment of the two groups lasted for six months. Compared the curative effect in the two groups. Observed the changes of scores of cognitive function which includes the Alzheimer's disease assessment scale-cognitive portion(ADAS-Cog) and severe impairment battery(SIB),the changes of scores of behavioral ability which includes behavior rating scale for dementia(BEHAVE-AD)and activities of daily living scale(ADL) as well as the changes of scores of negative emotion which includes Hamilton anxiety scale(HAMA) and Cornell scale for depression in dementia(CSDD) of patients before and after treatment. Results: After treatment of six months, the total effective rate was 93.62% in the treatment group, higher than that in the control group, which was 76.60%, the difference being significant(P〈0.05). ADAS-Cog scores in the two groups were decreased when compared with those before treatment,while the SIB scores were increased when compared with those before treatment, differences being significant(P〈0.05). ADAS-Cog score in the treatment group was lower than that in the control group(P〈0.05). Scores of BEHAVE-AD,ADL,HAMA and CSDD in the two groups were all decreased when compared with those before treatment,differences being significant(P〈0.01). The above four scores in the treatment group were lower than those in the control group(P〈0.01). Conclusion:Bushen Tianjing Yisui prescription can not only effectively improve cognitive function and beha
作者 迟淑梅 沈涌 CHI Shumei, SHEN Yong
出处 《新中医》 CAS 2018年第7期71-74,共4页 New Journal of Traditional Chinese Medicine
关键词 阿尔茨海默病(AD) 肾虚髓亏证 中西医结合疗法 补肾填精益髓方 认知功能 行为能力 焦虑 抑郁 Alzheimer's disease(AD) Syndrome of kidney marrow deficiency Integrated Chinese and western medicinetherapy Bushen Tianjing Yisui prescription Cognitive function Behavioral ability Anxiety Depression
作者简介 迟淑梅(1980-),女,医学硕士,主治医师,研究方向:阿尔茨海默病的诊断与治疗。;[通信作者]沈涌,E-mail:wj_791216@163.com。
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