Objective To investigate the effect of thalidomide combined with firstline chemotherapy on the serum VEGF level in the treatment of gastric carcinoma complicated with Krukenberg tumor.Methods The clinical data of 76 gastric carcinoma patients complicated with Krukenberg tumor treated in author＇s hospital from February 2003 to March 2015 were retrospectively analyzed.The patients were divided into two groups, each with 38 cases.The control group received firstline chemotherapy regimens, based on this, the observation group received the thalidomide.The short- term efficacy, 1 - year and 2 - year survival rates during fol- low- up period,incidence of toxic and side effect,and changes in serum VEGF levels and efficacy were com- pared between the two groups.Results The response rate and the tumor control rate were 65.79% and 68. 42% in the observation group, which were significantly higher than those in the control group （42.11%, 44.74% ,P〈0.05）.The 1 - year and 2 - year survival rates of the observation group were significantly higher than those of the control group （60.53% vs 36.84%,34.21% vs 13.16% ,P〈0.05）.The serum VEGF levels were decreased after treatment,and was lower in the observation group than in the control group （P〈0.05）. The decrease of serum VEGF levels was positively correlated with therapeutic efficacy after treatment （ r = 0.675,P〈0.05 ）. The incidence of side effects such as thrombocytopenia and leukopenia in the observation group was lower than that in the control group （P〈0.05）.Conelusion The shortterm efficacy of thalidomide combined with firstline chemotherapy in the treatment of gastric carcinoma complicated with Krukenberg tumor is significant,the treatment method can prolong the survival time,inhibit the serum VEGF levels. The decrease level of serum VEGF levels is positively correlated with therapeutic efficacy,suggesting that the levels have a certain assessment significance.
Chinese Journal of Coal Industry Medicine