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帕金森病伴发抑郁、焦虑状况及其相关因素调查 预览 被引量:2

Research of Conditions of Parkinson's Disease with Depression,Anxiety and Related Factors
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摘要 目的探讨帕金森病伴发抑郁、焦虑状况及相关危险因素。方法选取2016年2月至2017年4月在我院治疗的帕金森病患者173例,采用HAMD-17和HAMA评估患者抑郁及焦虑情况,采用UPDRS-Ⅲ和ADL量表评估运动功能和日常生活能力,MMSE评估认知功能。结果 173例患中伴发抑郁患者72例,发生率为41.62%;伴发焦虑患者75例,发生率为43.35%;同时伴发抑郁和焦虑患者54例,发生率为31.21%;有无抑郁、焦虑患者性别、年龄、病程、起病年龄、MMSE评分及左旋多巴胺日用量比较差异无统计学意义(P〉0.05)。伴发抑郁患者受教育年限为(8.20±2.11)年,明显短于非抑郁患者,差异有统计学意义(P〈0.05);而UPDRS-Ⅲ评分和ADL评分分别为(28.21±4.33)分和(38.10±8.04)分,明显高于非抑郁患者,差异有统计学意义(P〈0.05)。伴发焦虑患者受教育年限为(8.41±1.87)年,明显短于非抑郁患者,差异有统计学意义(P〈0.05);而UPDRS-Ⅲ评分和ADL评分分别为(28.01±4.01)分和(34.01±7.62)分,明显高于非焦虑患者,差异有统计学意义(P〈0.05)。Logistic回归分析显示受教育年限是帕金森病患者伴发抑郁的保护因素(OR=0.656),UPDRS-Ⅲ评分和ADL评分是帕金森病患者伴发抑郁的危险因素(OR=1.689和1.365;受教育年限是帕金森病患者伴发焦虑的保护因素(OR=0.662),UPDRS-Ⅲ评分是帕金森病患者伴发焦虑的危险因素(OR=1.738)。结论帕金森病伴发抑郁、焦虑的发生率较高,应针对相关危险因素加强健康教育和心理干预。 Objective To study depression,anxiety and related risk factors in Parkinson′s disease. Methods 173 cases of in patients with Parkinson′s disease were selected from February 2016 to April 2017 in our hospital.HAMD and HAMA were used to evaluate depression and anxiety,UPDRS-Ⅲ and ADL scale to evaluate daily life ability,and MMSE to assess cognitive function. Results Of the 173 patients,72 were associated with depression with the incidence of 41.62%.75 patients were associated with anxiety with the incidence of 43.35%.54 patients with both depression and anxiety were found with an incidence of 31.21%.There was no significant difference in gender,age,course of disease,onset age,MMSE score and levodopamine daily dose in patients with depression or anxiety or not( P 〉0.05).Patients with depression received education years(8.20±2.11)was significantly shorter than those of non-depressed patients,with statistically significant differences( P 〈0.05).UPDRS-Ⅲ scores(28.21±4.33)and ADL scores(38.10±8.04)were significantly higher than those patients without depression with statistically significant( P 〈0.05).The number of patients with anxiety was significantly smaller than that of non-depressed patients( P 〈0.05)with received education years(8.41±1.87).However,the UPDRS-Ⅲ grading score and ADL score were respectively(28.01±4.01)and(34.01 + 7.62),significantly higher than those of non-anxious patients,with statistically significant difference( P 〈0.05).Logistic regression analysis showed that the fixed number of year of the education is the protection of the Parkinson s disease patients with depression factor(OR=0.656),UPDRS-Ⅲ scores and ADL scores are risk factors for Parkinson s disease patients with depression(OR=1.689 and 1.365).The years received education is a protective factor for patients with Parkinson s disease(OR=0.662).UPDRS-Ⅲ rating is a risk factor for Parkinson s patients comorbid anxiety(OR=1.738). Conclusion The inci
作者 覃冰雁 曾丽红 杨志 马岸 郭冬 Tan Bingyan,Zeng Lihong,Yang Zhi,et al(Shenzhen Longhua New District People′s Hospital,Shenzhen,Guangdong 518109,China)
出处 《四川医学》 CAS 2018年第5期559-562,共4页 Sichuan Medical Journal
关键词 帕金森病 抑郁 焦虑 危险因素 Parkinson s disease;depression;anxiety;risk factors
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