Objective To investigate catheter-related bloodstream infections（CRBSI） in patients with hematologic malignancies（HM）, and pathogenic distribution as well as drug susceptibility. Methods A totally of 1,335 cases which were admitted into four hospitals were involved in this study. Species of pathogens as well as clinical information were recorded. Results Femoral vein catheter exerted the lowest incidence of CRBSI compared with internal jugular vein catheter and subclavian vein（P 〈 0.05）. Incidence of CRBSI was closely correlated with age, number of venipuncture, duration of catheter, standard treatment, WBC levels, diabetes mellitus and the usage of the hormone and immune inhibitor（P 〈 0.05）. Incidence of drug resistance of gram-negative bacteria against Cefoperazone/Sulbactam, Amikacin and Imipenem was generally less than 20.00%. Incidence of drug resistance of Acinetobacter Baumannii was generally over 50.00%, while that of pseudomonas aeruginosa, klebsiella pneumoniae and e. coli was less than 50.00%. No drug resistance of gram positive bacteria against Vancomycin, Rina Thiazole Amine and Tigecycline was identified. Incidence of drug resistance of pathogens against Rifampicin was less than 20.00%, while that against Penicillin, Benzene Azole Westwood, and Cefoperazone/Sulbactam was more than 50.00%. Conclusion Gram-negative bacteria is most common pathogen with prevailing drug resistance to various antibiotics in HM patients with venous catheters. Health care providers should standardize operations and choose appropriate antibiotics according to the pathogenic epidemiology.
China Journal of Modern Medicine
catheter related bloodstream infections