目的探讨正电子发射计算机断层显像（PET）在Ⅲ/Ⅳ期黑色素瘤转移中的应用价值。方法对经临床病理证实的黑色素瘤的9例患者行PET/CT检查,随访经3月的影像或病理资料证实为AJCC分期为Ⅲ/Ⅳ期,计算PET/CT与常规CT对于淋巴结及转移灶的检出率,应用SPSS 17. 0软件行配对资料X2检验,比较检出率的差异,并分别计算真阳性率与假阳性率之比。结果 PET/CT对淋巴结转移灶的检出率明显高于CT分别为91. 67%和37. 50%,差异有统计学意义（X2=6. 231,P=0. 014）,真假阳性率之比分别为5. 50和1. 12。PET/CT对远处转移灶的检出率（92. 11%）也高于常规CT（64. 47%）,差异有统计学意义（χ2=5. 944,P=0. 018）,真假阳性率之比5. 83及1. 26。结论 PET/CT能是一种较好的检测黑色素瘤转移灶的方法,较常规CT有较大优势。
Objective To explore the value for ^1 F-fluoro-deoxy-2-glocuse（^18F-FDG） PET-CT on metastasis for stage Ⅲ/Ⅸ malignant melanoma. Methods PET/CT was examined in 9 patients with clinically confirmed malignant melanom. After 3 months of follow-up,imaging or pathological data confirmed that the American Joint Committee on Cancer（AJCC） stage was Ⅲ/Ⅳ. The detection rates of lymph node and metastasis were calculated by PET/CT and conventional CT,the difference of detection rate was compared by using SPSS 17 paired data and chi 2 test,and the ratio of truly to false positive was calculated. Results The detection rates of lymph node metastasis by CT and PET/CT were respectively 37. 5% and 91. 67%,the ratio of truly to false positive was 1. 12 and 5. 50 respectively. For distant metastases,the detection rates were 64. 47% and 92. 11%,the ratio of truly to false positive was 1. 26 and 5. 83 respectively. The detection rate of PET/CT in lymph node metastasis and distant metastasis was significantly higher than that of conventional CT,the difference was both statistically significant（χ2= 6. 231,P = 0. 014; χ2= 5. 944,P = 0. 018）. Conclusion PET/CT is a better method for detecting metastasis of malignant melanoma,and had obviously advantage than conventional CT.
Journal of Medical Imaging