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低密度脂蛋白胆固醇变异性对老年认知功能的影响 预览

Effect of LDL-C variability on cognitive function in the elderly
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摘要 目的探讨LDL-C变异性对老年认知功能的影响。方法筛选济南市章丘区年龄≥60岁老年人436例,根据LDL-C变异性三分位分为低分位组143例、中分位组151例和高分位组142例。检测受试者血脂水平,并采用简易智能状态检查量表(MMSE)评估认知功能。结果 3组年龄、男性、吸烟、受教育水平、TC、LDL-C及LDL-C变异性水平比较,差异有统计学意义(P〈0.05,P〈0.01)。最后1次随访,低、中、高分位组MMSE评分、认知功能损伤发生率、MMSE评分变化值比较,差异有统计学意义[(27.88±1.329)分vs(27.79±1.36)分vs(27.45±1.345)分,7.0%vs 10.6%vs 15.5%,(-1.02±0.99)分vs(-1.22±1.00)分vs(-1.44±1.02)分,P〈0.05]。高分位组MMSE评分变化值明显高于低分位组,差异有统计学意义(P=0.004)。Spearman分析显示,LDL-C变异性与MMSE评分变化值呈负相关(P〈0.01)。校正混杂因素后,logistics回归分析显示,LDL-C变异性是认知功能损伤的独立危险因素(P〈0.05),高分位组发生认知功能损伤的危险为低分位组的2.551倍(P〈0.05)。结论高LDL-C变异性是老年人认知功能损伤的独立危险因素。 Objective To study the effect of LDL-C variability on cognitive function in the elderly.Methods Four hundred and thirty-six ≥60 years old subjects from Zhangqiu district of Jinan were divided into low tertile group(n=143),intermediate tertile group(n=151)and high tertile group(n=142)according to their LDL-C variability tertile.Their serum LDL-C level was measured.Their cognitive function was assessed according to the MMSE.Results The age,number of males,smoking history,education level,serum TC and LDL-C level,and LDL-C variability were significantly different in 3 groups(P〈0.05,P〈0.01).The MMSE score was higher while the incidence of cognitive impairment and changing MMSE score were lower in 3 tertile groups during the last follow-up(P〈0.05).The changing MMSE score was significantly higher in high tertile group than in low tertile group(P=0.004).Spearman correlation analysis showed that the LDL-C variability was negatively related with the MMSE score(P〈0.01).Logistic regression analysis revealed that LDL-C variability was an independent risk factor for cognitive impairment in elderly subjects after adjustment of confounders(P〈0.05).The risk of cognitive impairment was 2.551-fold higher in high tertile group than in low tertile group(P〈0.05).Conclusion Elevated LDL-C variability is an independent risk factor for cognitive impairment in the elderly.
作者 王会芳 王新国 周婷婷 李云鹏 王雷清 赵颖馨 柴强 刘振东 张华 Zhao Yingxin,Chai Qiang,Liu Zhendong, Zhang Hua (Institute of Basic Medical Sciences, Shandong Academy of Medical Sciences, Jinan 250200 , Shandong Province, China)
出处 《中华老年心脑血管病杂志》 CAS 北大核心 2018年第10期1045-1048,共4页 Chinese Journal of Geriatric Heart,Brain And Vessel Diseases
基金 国家自然科学基金(81670432,81470489) 山东省重点研发计划(2017GSF218060) 山东省自然科学基金(ZR2016HM82) 山东省医药卫生科技发展计划(2016WS0527,2017WS076) 山东省医学科学院院级科技计划(2017-32)
关键词 胆固醇 LDL 认知障碍 高血压 高血糖症 cholesterol LDL cognition disorders hypertension hyperglycemia
作者简介 通信作者:张华,Email:21hua@sina.com
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