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Regulatory Effect of General Anesthetics on Activity of Potassium Channels

Regulatory Effect of General Anesthetics on Activity of Potassium Channels
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摘要 一般麻醉是麻药为外科导致的一个无意识的状态。分子的目标和在哺乳动物的神经系统的一般麻药的细胞的机制在过去的十年期间被调查了。在最近的年里, K <sup>+</sup> 隧道作为不稳定、静脉内的麻药的重要目标被识别了。这评论盖住在 K <sup>+</sup> 隧道和他们的内在的机制的活动在一般麻药的规章的效果上被成为了两个的成就。在关于由一般麻药的 K <sup>+</sup> 隧道的调整的研究的进展基于他们的氨基酸的顺序相同根据四个大 K <sup>+</sup> 隧道家庭的意见被总结并且分类。另外,在 vivo 在一般麻醉在 K <sup>+</sup> 隧道的角色上研究成就,特别关于用有 K <sup>+</sup> 隧道大美人的老鼠的研究,特别地被强调。 General anesthesia is an unconscious state induced by anesthetics for surgery. The molecular targets and cellular mechanisms of general anesthetics in the mammalian nervous system have been investigated during past decades. In recent years, K+ channels have been identified as important targets of both volatile and intra- venous anesthetics. This review covers achievements that have been made both on the regulatory effect of general anesthetics on the activity of K+ channels and their underlying mechanisms. Advances in research on the modulation of K~ channels by general anesthetics are summarized and categorized according to four large K+ channel families based on their amino-acid sequence homology. In addition, research achievements on the roles of K+ channels in general anesthesia in vivo, especially with regard to studies using mice with K+ channel knockout, are particularly emphasized.
作者 Yan Li Jie Xu Yun Xu Xiao-Yun Zhao Ye Liu Jie Wang Guang-Ming Wang Yan-Tian Lv Qiong-Yao Tang Zhe Zhang Yan Li[1][2]; Jie Xu[1][2]; Yun Xu[1][2]; Xiao-Yun Zhao[1][2]; Ye Liu[1][2]; Jie Wang[1][2]; Guang-Ming Wang[1][2]; Yan-Tian Lv[1][2]; Qiong-Yao Tang[1][2]; Zhe Zhang[1][2]
出处 《神经科学通报:英文版》 SCIE CAS CSCD 2018年第5期887-900,共14页 Neuroscience Bulletin
关键词 隧道 规章 神经系统 哺乳动物 VIVO 不稳定 氨基酸 General anesthesia Potassium channel Ion channel
作者简介 Zhangzhe70@ xzhmu.edu.cn
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