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咳露口服液降低AR小鼠鼻黏膜AQP5表达及减轻其鼻腔炎症 预览

Kelu Oral Liquid Reduces the Expression of AQP5 in Nasal Mucosa of Allergic Rhinitis Mice and Alleviates Nasal Inflammation
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摘要 目的研究咳露口服液对AR小鼠鼻腔炎症及AQP5表达的影响。方法将18只BALB/c小鼠随机分为对照组、鼻炎组和咳露口服液组,各6只。鼻炎组和咳露口服液组建立AR模型。对照组、鼻炎组生理盐水灌胃,咳露口服液组咳露灌胃,比较3组血清OVA sIgE等变化。结果鼻炎组所有指标均显著增高(P <0.05)。咳露口服液组和对照组比较差异无统计学意义(P> 0.05)。结论咳露口服液可减轻AR小鼠鼻黏膜炎症,降低细胞因子分泌和AQP5表达,对AR小鼠鼻黏膜有保护作用。 Objective To study the effect of Kelu oral liquid on nasal inflammation and aquaporin 5(AQP5)expression in allergic rhinitis mice.Methods Eighteen female BALB/c mice were randomly divided into control group,rhinitis group and Kelu oral liquid group,6 mice in each group.In addition to the control group,the other two groups established a mouse model of allergic rhinitis.The control group and the rhinitis group were given 0.9%NaCl solution by gavage,and the Kelu oral liquid group was given Kelu by gavage.Serum OVA sIgE and so on in the three groups were compared.Results All indicators were significantly increased in the rhinitis group(P<0.05).There was no significant difference between kelu oral liquid group and control group(P>0.05).Conclusion Kelu oral liquid can reduce the inflammation of nasal mucosa,reduce the secretion of cytokines and the expression of AQP5,and have a protective effect on the nasal mucosa of mice with allergic rhinitis.
作者 赵梅珍 ZHAO Meizhen(Department of Clinical Laboratory,Longgang E.N.T Hospital&Shenzhen Key Laboratory of E.N.T,Institute of E.N.T,Shenzhen 518172,China)
出处 《大医生》 2019年第3期54-55,共2页 Doctor
基金 深圳市龙岗区经济与科技发展专项资金(LGKCYLWS2018000194).
关键词 咳露口服液 AR 水通道蛋白5 kelu oral liquid allergic rhinitis aquaporin 5
作者简介 通信作者:赵梅珍,硕士研究生,主管检验师,研究方向:过敏反应,E-mail:zhaomeizhen8435@sohu.com。
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