目的 通过比较四种常用实验动物小鼠、大鼠、豚鼠、家兔的肝与人的肝在组织形态上的相似性,为肝研究中实验动物的选择提供参考。方法 分别取正常小鼠、大鼠、豚鼠、家兔的肝,从形态特征、分叶、脏器系数、肝细胞核浆比等方面与人的肝进行比较。结果 家兔肝的形态与人的最接近,为不规则楔形及楔形,二者的核浆比亦最相近,分别为0.158和0.149。豚鼠与人的肝均为五叶,且脏器系数最接近,分别为3.096%和2.35%。结论家兔和豚鼠在组织形态特征上与人更接近,可能更适合进行肝相关研究。
Objective To compare the livers of four commonly used laboratory animals(mouse,rat,guinea pig,and rabbit)with the human liver regarding tissue morphology,in order to provide a reference for study of the liver and the choice of laboratory animal.Methods Livers of normal mice,rats,guinea pigs,and rabbits were obtained.The morphology,hepatic lobules,organ coefficient,and nucleoplasm ratio of the livers of the four animals were investigated and compared with those of human.Results The results showed that the morphological characteristics of rabbit liver were the most similar to those of human liver,and the shapes of rabbit liver and human liver were irregular wedge and wedge,respectively.The nucleoplasm ratio of rabbit was also the closest to that of human,at 0.158 and 0.149,respectively.The hepatic lobules of guinea pig were the closest to those of human,with both five lobules.The liver coefficient of guinea pig was also the closest to that of human,at 3.096%and 2.35%,respectively.Conclusions The organization and morphological characteristics of the liver of rabbit and guinea pig are closest to human,so these two animals may be more suitable for liver-related research.
Chinese Journal of Comparative Medicine
tissue morphological characteristics
laboratory animal choice
李靖(1989— ),女,助教,研究方向:高原病分子机制研究。E-mail:email@example.com;通信作者,刘恩岐(1965— ),男,教授,研究方向:动脉粥样硬化。E-mail:firstname.lastname@example.org。