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深圳地区乙型肝炎病毒携带者人白细胞抗原C等位基因多态性分布特点 预览

Distribution characteristics of polymorphism of human leukocyte antigen C of hepatitis B virus carriers in patients from Shenzhen
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摘要 背景:目前,较多文献是研究乙型肝炎病毒与人白细胞抗原(human leukocyte antigen,HLA)A、B、DR之间的关系,较少文献报道乙型肝炎病毒与HLA-C的相关性,可能与HLA基因型检测方法的发展有关系。目的:研究深圳地区乙型肝炎病毒携带者HLA-C等位基因多态性分布特征。方法:应用聚合酶链反应-直接测序分型法分别对186名深圳地区健康人群(对照组)和122名乙型肝炎病毒携带者HLA-C基因进行基因分型。结果与结论:在对照组中检出的HLA-C等位基因有24种,其中HLA-C*01:02、07:02、03:04以及08:01最为常见;携带组检出HLA-C等位基因有18种,常见等位基因有HLA-C*07:02、01:02、03:04、08:01。携带组中未检出基因HLA-C*12:02,对照组HLA-C*12:02检出率显著高于携带组,提示深圳地区乙型肝炎病毒携带者HLA-C等位基因频率分布与对照组比较同样具有高度的遗传多态性。HLA-C*12:02基因可能与深圳地区感染乙型肝炎病毒的机会呈负相关性。 BACKGROUND:Due to the development of human leukocyte antigen(HLA)typing techniques,there are a large number of studies reporting the relationship between hepatitis B virus(HBV)and HLA-A,-B,and-DR,but little is reported on the relationship between HBV and HLA-C.OBJECTIVE:To analyze the polymorphism of HLA-C of HBV carriers in Shenzhen.METHODS:PCR-based typing method was used to analyze the polymorphism of HLA-C locus alleles of 122 HBV carriers and 186 healthy volunteers(control group)in Shenzhen.RESULTS AND CONCLUSION:Twenty-four alleles for the locus HLA-C were detected in the control group,of which HLA-C*01:02,07:02,03:04 and 08:01 were the most common.In the HBV carrier group,18 kinds of HLA-C alleles were detected,including the common alleles HLA-C*07:02,01:02,03:04,08:01.HLA-C*12:02 was not detected in the HBV carries group.The detection rate of HLA-C*12:02 in the control group was significantly higher than that in the HBV carrier group.These results imply that the frequency distribution of HLA-C alleles of HBV carriers in Shenzhen also have a high degree of genetic polymorphism compared with the control group.There may be association between HBV carriers and HLA-C*12:02 alleles.HLA-C*12:02 allele possibly plays a negative role in HBV carriers in Shenzhen.
作者 全湛柔 何柳媚 陈浩 洪文旭 高素青 Quan Zhanrou;He Liumei;Chen Hao;Hong Wenxu;Gao Suqing(Institute of Blood Transfusion of Shenzhen Blood Center,Shenzhen 518020,Guangdong Province,China)
出处 《中国组织工程研究》 CAS 北大核心 2019年第3期482-486,共5页 Journal of Clinical Rehabilitative Tissue Engineering Research
基金 深圳市科技计划项目(JCYJ20160425100217087),项目负责人:高素青。
作者简介 全湛柔,女,1991年生,广东省湛江市人,汉族,2016年广东医科大学毕业,初级检验技师,主要从事人白细胞抗原组织配型高分辨确认实验。
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