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不同剂量纳美芬治疗酒精与安眠药混合中毒临床疗效对比 预览 被引量:1

Comparative Effect of Different Doses of Namefen Hydrochloride Injection in the Treatment of Alcoholic and Sleeping Pills Poisoning
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摘要 目的对比不同剂量盐酸纳美芬注射液治疗酒精与安眠药混合中毒的临床疗效。方法选取医院2016年8月至2018年2月收治的酒精与安眠药混合中毒患者140例,采用回顾性分析法分析患者的临床资料,按药物剂量分为A组(42例)、B组(50例)和C组(48例)。A组患者予以常规治疗,B组、C组患者在此基础上予以盐酸纳美芬注射液(剂量分别为0.5μg/kg和1.0μg/kg)治疗。结果B组、C组临床总有效率明显高于A组(P<0.05),B组、C组间比较无显著差异(P>0.05);治疗后,3组患者肝功能指标水平均明显下降(P<0.05),其中B组、C较A组下降明显(P<0.05),B组较C组下降更明显(P<0.05);B组、C组患者清醒时间、症状消失时间均短于A组(P<0.05);B组、C组患者清醒后头晕乏力、胃肠不适、精神萎靡不适症状发生率明显低于A组(P<0.05)。结论剂量为0.5μg/kg和1.0μ/kg盐酸纳美芬注射液治疗酒精与安眠药混合中毒临床疗效确切,其中0.5μg/kg盐酸纳美芬注射液能更好地保护肝功能,值得临床应用。 Objective To compare the clinical effect of different doses of Namefen Hydrochloride Injection in the treatment of alcoholic and sleeping pills poisoning.Methods Totally140patients with alcoholic and sleeping pills poisoning admitted to our hospital from August2016to February2018were selected,and the clinical data of the patients were analyzed retrospectively.According to the doses,the patients were divided into group A(42cases),group B(50cases)and group C(48cases).The patients in group A were given routine treatment,while the patients in group B and group C were given Namefen Hydrochloride Injection on the basis of routine treatment at doses of0.5μg/kg and1.0μg/kg,respectively.Results The clinical total effective rates of group B and group C were significantly higher than that of group A(P<0.05),but there was no significant difference between group B and group C(P>0.05).After treatment,the levels of liver function indexes in the three groups were significantly decreased(P<0.05),those in group B and group C were significantly lower than those in group A(P<0.05),while those in group B were significantly lower than those in group C(P<0.05).The time of awakening and disappearance of symptoms in group B and group C was shorter than that in group A(P<0.05).The incidence rate of dizziness and fatigue,gastro-intestinal and mental malaise in group B and group C after awakening was significantly lower than that in group A(P<0.05).Conclusion Namefen Hydrochloride Injection with doses of0.5μg/kg and1.0μg/kg has definite clinical effect in the treatment of alcoholic and sleeping pills poisoning.Namefen Hydrochloride Injection with doses of0.5μg/kg can better protect liver function and it is worthy of clinical application.
作者 顾巍峰 顼志兵 GU Weifeng;XU Zhibing(Department of Emergency,Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University,Shanghai,China201700;Department of Emergency,The Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China201700)
出处 《中国药业》 CAS 2019年第1期60-62,共3页 China Pharmaceuticals
关键词 酒精中毒 安眠药中毒 盐酸纳美芬 剂量 临床疗效 alcoholic poisoning sleeping pills poisoning namefen hydrochloride dose clinical effect
作者简介 第一作者:顾巍峰,男,大学本科,主治医师,主要从事急诊危重症的治疗工作,(电子信箱)4946113@qq.com;通信作者:顼志兵,男,博士研究生,副主任医师,副教授,硕士研究生导师,研究方向为专业急危重症中西医结合,(电话)021-50402700
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