期刊文献+

肺表面活性制剂治疗新生儿呼吸窘迫综合征的效果和安全性分析 预览

Effect and Safety of Pulmonary Surfactant in the Treatment of Neonatal Respiratory Distress Syndrome
在线阅读 下载PDF
收藏 分享 导出
摘要 目的:进一步分析肺表面活性制剂治疗新生儿呼吸窘迫综合征的效果及探寻其的安全性。方法:选取本院2015年7月-2017年9月收治的新生儿呼吸窘迫综合征患儿82例作为研究对象,按入院时间随机将其分为观察组和对照组,各41例。对照组给予常规治疗,观察组在对照组的基础上加入肺表面活性制剂给予气管内给药治疗,观察比较两组的临床疗效、氧疗、住院、机械通气时间、住院费用及并发症发生情况。结果:治疗后观察组的总有效率为92.68%,明显高于对照组的73.17%,差异有统计学意义(χ^2=5.513,P=0.019)。观察组氧疗、住院、机械通气时间及住院费用均明显少于对照组,差异均有统计学意义(P<0.05)。观察组并发肺部感染2例,肺气漏3例,肺出血2例;对照组肺部感染10例,肺气漏13例,肺出血11例。观察组并发症总发生率为17.07%,明显低于对照组的82.93%,差异有统计学意义(χ^2=35.561,P<0.001)。结论:肺表面活性制剂治疗新生儿呼吸窘迫综合征,可有效减轻并发症,具有较好的疗效,安全性大大提高。 Objective:To further analyze the effect and safety of pulmonary surfactant in the treatment of neonatal respiratory distress syndrome.Method:A total of 82 cases of neonatal respiratory distress syndrome admitted in our hospital from July 2015 to September 2017 were selected as the research objects.According to the admission time,they were randomly divided into observation group and control group,41 cases in each group.The control group was given routine treatment,the observation group was given intratracheal administration of pulmonary surfactant on the basis of the control group.The clinical efficacy,oxygen therapy,hospitalization,mechanical ventilation time,hospitalization expenses and complications between the two groups were observed and compared.Result:After treatment,the total effective rate of the observation group was 92.68%,which was significantly higher than 73.17%of the control group,the difference was statistically significant(χ^2=5.513,P=0.019).The time of oxygen therapy,hospitalization,mechanical ventilation and hospitalization expenses in the observation group were significantly less than those in the control group,the differences were statistically significant(P<0.05).There were 2 cases of pulmonary infection,3 cases of pulmonary gas leakage and 2 cases of pulmonary hemorrhage in the observation group,10 cases of pulmonary infection,13 cases of pulmonary gas leakage and 11 cases of pulmonary hemorrhage in the control group.The total incidence of complications in the observation group was 17.07%,which was significantly lower than 82.93%in the control group,the difference was statistically significant(χ^2=35.561,P<0.001).Conclusion:Pulmonary surfactant in the treatment of neonatal respiratory distress syndrome can effectively reduce complications,has a good curative effect and safety is greatly improved.
作者 崔锐华 CUI Ruihua(The Second People’s Hospital of Jingzhou City,Jingzhou 434000,China)
出处 《中国医学创新》 CAS 2019年第1期36-39,共4页 Medical Innovation of China
基金 湖北省卫生厅科研基金项目(JX2C42).
关键词 肺表面活性制剂 新生儿呼吸窘迫综合征 安全性 Pulmonary surfactant Neonatal respiratory distress syndrome Safety
作者简介 通信作者:崔锐华
  • 相关文献

参考文献20

二级参考文献239

  • 1邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].第4版.北京:人民卫生出版社,2011:872. 被引量:414
  • 2金汉珍 黄德珉 官希吉.实用新生儿学[M]第3版[M].北京:人民卫生出版社,2002.421-656. 被引量:151
  • 3金汉珍,黄德珉,官希吉.实用新生儿学[M].第三版.北京:人民卫生出版社,2009:421-428. 被引量:1
  • 4A1 Faleh K, Liew K, Anabrees J, et al. Success rate and neonatal morbidities associated with early extubation in extremely low birth weight infants [J]. Ann Saudi Med, 2011, 31 (6): 577 -580. 被引量:1
  • 5尹晓娟,罗分平,李爱华,安育林,封志纯.20例汉族新生儿呼吸窘迫综合征肺表面活性物质蛋白遗传缺陷的研究[J].中华儿科杂志,2008(1):9-12. 被引量:9
  • 6Zuo YY,Veldhuizen R,Nemnann AW,et al.Current pempeetives inpulmonary surfattant inhilfition,enhancementand evaluation[J].Biochim Biophys Acta,2008,1778(10):1947-1977. 被引量:1
  • 7Raghavendran K,Pryhuber GS,Chess PR,et al.Pharmacotherapy of a-cute lung injury and acute respiratory distress syndrome[J].Curr Med Chem,2008,15(19):111-1924. 被引量:1
  • 8Hilgendorff A,Aslan E,Schaible T,et al.Surfactant replacement andopen lung concept-comparison of two treatment strategies in an experi-mentalmodel of neonatal ARDS[J].BMC Pulm Med,2008,8:10. 被引量:1
  • 9Engie WA,American Academy of Pediatrics Committee on Fetus and Newborn.Age teminology during the perinatal period[J].Pediatrics,2012,114(5):1362-1364. 被引量:1
  • 10Avital A, Hevroni A, GndtYey S, et al. Natural histol3' of five children with surfactant protein C nmtations and interstitial lung disease. Pediatr Pulmonol. 2014, 49(11) : 1097-1105. 被引量:1

共引文献210

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈