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系统性硬化症相关自身抗体的临床意义 预览

Clinical Significance of Autoantibodies in Systemic Sclerosis
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摘要 系统性硬化症(SSc)是常见的自身免疫性结缔组织病之一,病因未明确,主要发病机制为免疫失调、血管病变、皮肤及内脏器官的过度纤维化。免疫失调产生多种针对自身组织、细胞或成分的循环自身抗体,且自身抗体往往产生于病程早期,出现在临床表现前。目前已发现越来越多的SSc相关自身抗体与临床表现、疾病过程、临床并发症及预后存在明显关联,总结SSc相关自身抗体的临床意义对SSc的早期诊断、病情评估、并发症预测及预后判断尤为重要。 Systemic sclerosis(SSc)is one of the common autoimmune connective tissue diseases.The etiology is not clear.The main pathogenesis is immune dysregulation,vasculopathy,excessive fibrosis of skin and visceral organs.Immune dysregulation produces various circulating autoantibodies which target against their own tissues,cells or components.Furthermore,these autoantibodies usually are produced in early course of the disease before its clinical manifestations.A great deal of studies have found that more and more autoantibodies are significantly correlated with the heterogeneous clinical manifestations,disease process,complications and prognosis of SSc.Therefore,to summarize the clinical significance of SSc-related autoantibodies is particularly important for the early diagnosis,evaluation,complication prediction and prognosis of SSc.
作者 刘合会 邓丹琪 LIU Hehui;DENG Danqi(Department of Dermatology,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)
出处 《医学综述》 2019年第1期113-118,共6页 Medical Recapitulate
关键词 系统性硬化症 硬皮病 自身免疫性疾病 自身抗体 Systemic sclerosis Scleroderma Autoimmune disease Autoantibodies
作者简介 通信作者:邓丹琪E-mail:danqid128@sina.com
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