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合肥市一岁以下儿童临床诊断类百日咳综合征378例临床特征分析 预览

Analysis of clinical features of 378 cases of clinical diagnosed pertussis syndrome in children under one year old in Hefei city
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摘要 目的分析合肥市一岁以下儿童临床诊断类百日咳综合征的临床特征。方法回顾性分析378例一岁以下临床诊断为类百日咳的病历,比较不同分组下相关临床症状例数、治疗上使用丙球的例数及平均住院天数。结果年龄小于等于3个月组患儿在鸡鸣样回声、面色发绀、住院天数及丙种球蛋白的使用率等方面均明显高于年龄大于3个月组,差异有统计学意义(P=0.048;P=0.026;P=0.012;P<0.001)。未接种百白破疫苗组患儿鸡鸣样回声、面色发绀、住院天数、入院时白细胞计数及丙种球蛋白的使用率等方面,均明显高于已接种百白破疫苗组,差异有统计学意义(P<0.001;P<0.001;P=0.024;P=0.018;P<0.001)。红霉素组平均住院日较阿奇霉素组短,使用丙球例数较阿奇霉素少,差异无统计学意义。结论合肥市一岁以下儿童临床诊断类百日咳综合征的患儿,≤3月龄、未接种疫苗者病情较重;百白破疫苗的接种有助于类百日咳的预防;红霉素及阿奇霉素两种抗生素疗效差异不明显。 Objective To analysis the clinical features of clinical diagnosed pertussis syndrome in children under one year old in Hefei city.Methods A retrospective analysis was conducted on 378 cases of clinical diagnosed of pertussis syndrome below the age of one year.The number of relevant clinical symptoms,the number of cases of the use of Gamma globulin in treatment and the average days of hospitalization were compared among different groups.Results Children aged less than or equal to 3 months were significantly higher than those older than 3 months in terms of chicken-like echoes,facial blisters,days of hospitalization,and the use of Gamma globulin(P=0.048;P=0.026;P=0.012;P<0.001).The children with non-vaccination Vaccine group had significantly higher than those who had received DPT vaccine,and the differences were statistically significant in terms of chicken-like echoes,facial blisters,days of hospitalization,leukocyte counts on hospital admissions,and the use rate of Gamma globulin(P<0.001;P<0.001;P=0.024;P=0.018;P<0.001).The mean duration of hospital stay in the erythromycin group was shorter than that in the azithromycin group,and there were fewer cases of using Gamma globulin than azithromycin(P>0.05).Conclusion Children≤3 months of age and without vaccination clinically diagnosed as pertussis syndrome have serious condition.DPT vaccine is helpful for the prevention of pertussis syndrome,and the difference of clinical efficacy between erythromycin and azithromycin is not obvious.
作者 张旭中 潘家华 ZHANG Xu-zhong;PAN Jia-hua(Department of Pediatrics,the First Affiliated Hospital of China Science and Technology University,Hefei,Anhui 230001,China)
出处 《临床肺科杂志》 2019年第2期258-261,共4页 Journal of Clinical Pulmonary Medicine
关键词 类百日咳综合征 临床诊断 儿童 临床特征 pertussis syndrome clinical diagnosis child clinical features
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