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Differential hepatic features presenting in Wilson disease-associated cirrhosis and hepatitis B-associated cirrhosis 预览

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摘要 BACKGROUND Cirrhosis is a chronic late stage liver disease associated with hepatitis viruses,alcoholism,and metabolic disorders,such as Wilson disease(WD).There are no clear markers or clinical features that define cirrhosis originating from these disparate origins.We hypothesized that cirrhosis is not one disease and cirrhosis of different etiology may have differential clinical hepatic features.AIM To delineate the liver features between WD-associated cirrhosis and hepatitis Bassociated cirrhosis in the Chinese population.METHODS In this observational study,we reviewed the medical data of consecutive inpatients who had WD-associated cirrhosis or hepatitis B-associated cirrhosis from January 2010 to August 2018,and excluded patients who had carcinoma,severe heart or pulmonary diseases,or other liver diseases.According to the etiology of cirrhosis,patients were divided into two groups:WD-associated cirrhosis group(60 patients)and hepatitis B-associated cirrhosis group(56 patients).The liver fibrosis degree,liver function indices,and portal hypertension features of these patients were compared between the two groups.RESULTS No inter-group differences were observed in the diagnostic liver fibrosis markers,however,clinical features clearly defined the origin of cirrhosis.WD-associated cirrhosis patients(16-29 years)had lower levels of alanine transaminase,aspartate transaminase,and bilirubin,lower prothrombin time,lower incidence of hepatic encephalopathy,and lower portal vein diameter(P<0.05),compared to cirrhosis resulting from hepatitis B in older patients(45-62 years).Importantly,they had decreased risks of progression from Child-Pugh grade A to B(odds ratio=0.046,95%confidence interval:0.006-0.387,P=0.005)and of ascites(odds ratio=0.08,95%confidence interval:0.01-0.48,P=0.005).Conversely,WDassociated cirrhosis patients had a higher risk of splenomegaly(odds ratio=4.15,95%confidence interval:1.38-12.45,P=0.011).CONCLUSION WD-associated cirrhosis presents a higher risk of splenomegaly associated with leukopenia a
出处 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第3期378-387,共10页 World Journal of Gastroenterology
基金 the Science and Technology Planning Project of Guangdong Province,No.2015A030302085 No.2016A020212022.
作者简介 Corresponding author:Yu Chen,MD,PhD,Doctor,Department of Gastroenterology,The First Affiliated Hospital of Guangdong Pharmaceutical University,No.19,Nonglinxia Road,Guangzhou 510000,Guangdong Province,China.yuchen@gdpu.edu.cn,Telephone:86-138-24462875Fax:+86-020-61325957
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