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肿瘤靶向基因输送载体的研究进展 预览

Development in the study of cancer targeted gene delivery vector
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摘要 基因治疗是通过引入外源性核酸永久或暂时取代缺陷基因的一种新兴技术。肿瘤的基因治疗是继化学治疗之后的一种极有潜力的治疗方法。近年来,全球进行了大量的肿瘤基因治疗临床试验。但基因治疗常常因缺乏选择性产生非特异性毒性。基因输送载体是肿瘤基因治疗的关键,理想的基因输送载体应该对靶细胞具备高效的基因转导性能,并对人体安全性高。如何提高基因输送的靶向性,开发高效低毒的基因输送载体是目前肿瘤基因治疗的一项重要挑战。国内外学者进行了大量研究开发新型靶向性载体和技术来提高基因表达的特异性。本文总结了目前常用的肿瘤靶向基因输送载体及相应的输送策略。 Gene therapy is an emerging technology that could replace defective gene with exogenous nucleci acids permanently or transiently.Cancer gene therapy is a potentially beneficial approach particularly over chemotherapy.In recent years,a large number of cancer gene therapy clinical trials have been carried out.However,gene therapy lacks selectivity and can cause non-specific toxicity.Gene delivery vector is the key to cancer gene therapy,an ideal gene delivery vector should have high transduction efficiency and is safe to human.How to improve the specificity of gene delivery and develop gene delivery vector with high efficiency and low toxicity is considered a major challenge.Researchers at home and abroad have done a lot of study to develop novel targeting vectors and technology to improve the specificity of gene expression.This review concludes the frequently used gene delivery vectors and the related strategies in cancer targeted gene delivery.
作者 张海红 刘永飞 Zhang Haihong;Liu Yongfei(Jiangxi Health Vocational College,Jiangxi Nanchang 330052,China)
出处 《现代肿瘤医学》 CAS 2019年第3期520-524,共5页 Modern Oncology
关键词 肿瘤 靶向 基因输送 载体 cancer target gene delivery vector
作者简介 张海红(1987-),女,江西人,主管药师,主要从事药剂学教学及研究工作。E-mail:zhanghaihongdyx@126.com
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