期刊文献+

恩替卡韦联合乳果糖治疗乙型肝炎后肝硬化的临床疗效分析 预览

The effect of entecavir combined with lactulose in the treatment of liver cirrhosis after hepatitis B
在线阅读 免费下载
分享 导出
摘要 目的:探讨恩替卡韦联合乳果糖治疗乙型肝炎(乙肝)后肝硬化的临床疗效。方法:选取2015年8月至2017年8月四川省巴中市中心医院收治的96例乙肝后肝硬化患者,按随机数字表法分为观察组(n=48)和对照组(n=48)。对照组采用恩替卡韦治疗,观察组采用恩替卡韦联合乳果糖治疗。治疗3个月后,比较两组治疗前、后肝功能、肝纤维指标、肠黏膜屏障功能、肝功能Child-Pugh评分,并评价治疗期间安全性。结果:治疗后,两组血清天门冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、总胆红素(TBil)、透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(ⅣC)、内毒素、二胺氧化酶(DAO)、D-乳酸水平及肝功能Child-Pugh评分均显著降低,且观察组明显低于对照组(均P<0.05)。两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。观察组自发性腹膜炎发生率明显低于对照组(P<0.05)。结论:恩替卡韦联合乳果糖治疗乙肝后肝硬化患者效果显著,可有效改善患者肝功能,抑制肝纤维化,保护肠黏膜屏障功能,且安全性好,值得临床推广应用。 Objective:To study the effect of entecavir combined with lactulose in the treatment of liver cirrhosis after hepatitis B. Methods:96 patients with liver cirrhosis after hepatitis B treated in our hospital from August 2015 to August 2017 were selected,and randomized to receive either entecavir combined with lactulose(observation group, n =48) or entecavir only(control group, n =48).The liver function,hepatic fibrosis,intestinal mucosal barrier function,Child-Pugh score and adverse reactions were assessed. Results:After treatment,the aspartate aminotransferase(AST),alanine transaminase(ALT),total bilirubin(TBil),hyaluronic acid(HA),laminin(LN),type Ⅲ procollagen(PC Ⅲ),type Ⅳ collagen(Ⅳ C),endotoxin,diamineoxidase(DAO),D-lactic acid levels as well as the Child-Pugh score were significantly decreased in both groups( P< 0.05),and the changes were more significant in the observation group( P< 0.05).There was no significant difference in the incidence of adverse reactions between the two groups( P >0.05).The incidence of spontaneous peritonitis in the observation group was markedly lower than that of the control group( P <0.05). Conclusion:Entecavir combined with lactulose was effective in the treatment of liver cirrhosis after hepatitis B.It could improve the liver function,inhibit hepatic fibrosis,protect the intestinal mucosal barrier function,and was safe.
作者 易鸣 李虎 罗波 Yi Ming;Li Hu;Luo Bo(Department of Gastroenterology,The Central Hospital of Bazhong,Bazhong 636000,China)
出处 《广西医科大学学报》 CAS 2019年第2期204-208,共5页 Journal of Guangxi Medical University
关键词 乙型肝炎后肝硬化 恩替卡韦 乳果糖 肝纤维化 肠黏膜屏障功能 liver cirrhosis after hepatitis B entecavir lactulose hepatic fibrosis intestinal mucosal barrier function
  • 相关文献

参考文献10

二级参考文献256

共引文献12649

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈