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乙醛脱氢酶2基因G487A位点多态性与老年2型糖尿病患者冠状动脉狭窄及其严重程度的关系研究 预览

Relationship between ALDH2 Gene G487A Polymorphism and Coronary Artery Stenosis and Its Severity in Elderly Patients with Type 2 Diabetes Mellitus
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摘要 背景 冠心病和2 型糖尿病(T2DM)均是受遗传和环境等多因素影响的疾病。近年来,酒精代谢酶基因尤其是乙醛脱氢酶2(ALDH2)基因被疑在冠心病和T2DM 发病中具有重要作用,但ALDH2 基因多态性与老年T2DM 患者冠状动脉狭窄的关系尚不明确。目的 探讨ALDH2 基因G487A 位点多态性与老年T2DM 患者冠状动脉狭窄及其严重程度的关系。方法 选取2015 年10 月—2016 年10 月海口市人民医院收治的老年T2DM 并冠状动脉狭窄患者60 例作为研究组,另选取同期老年T2DM 患者54 例作为对照组。比较两组患者一般资料、实验室检查指标及基因型、等位基因分布频率,老年T2DM 患者冠状动脉狭窄的影响因素分析采用多因素Logistic 回归分析;比较不同基因型老年T2DM 并冠状动脉狭窄患者Gensini 积分和冠状动脉病变支数,基因型与老年T2DM 并冠状动脉狭窄患者Gensini 积分和冠状动脉病变支数的相关性分析采用Spearman 秩相关分析。结果 (1)两组患者性别、年龄、体质指数(BMI)、吸烟率及血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、纤维蛋白原(FIB)水平比较,差异无统计学意义(P>0.05);研究组患者饮酒量大于对照组,饮酒面红反应发生率高于对照组(P<0.05)。(2)两组患者基因型及等位基因分布频率比较,差异有统计学意义(P<0.05)。(3)多因素Logistic 回归分析结果显示,饮酒量〔OR=2.962,95%CI(1.899,4.622)〕、饮酒面红反应〔OR=3.408,95%CI(2.303,5.043)〕及基因型〔OR=3.431,95%CI(2.451,4.804)〕是老年T2DM 患者冠状动脉狭窄的独立影响因素(P<0.05)。(4)不同基因型老年T2DM 并冠状动脉狭窄患者Gensini 积分和冠状动脉病变支数比较,差异有统计学意义(P<0.05)。(5)Spearman 秩相关分析结果显示,基因型与老年T2DM 并冠状动脉狭窄患者Gensini 积分(rs=0.451)、冠状动脉病变支数(rs=0.412)呈正相关(P<0.05)。 Background Coronary heart disease and type 2 diabetes mellitus(T2DM)are affected by multiple factors,such as genetic and environmental factors. Alcohol metabolizing enzyme genes especially aldehyde dehydrogenase 2 (ALDH2)gene have been supposed to play an important role in the pathogenesis of coronary heart disease and T2DM in recent years. However,relationship between ALDH2 gene polymorphism and coronary artery stenosis in elderly patients with T2DM is not clear. Objective To investigate the relationship between ALDH2 gene G487A polymorphism and coronary artery stenosis and its severity in elderly patients with T2DM. Methods Sixty elderly T2DM patients complicated with coronary artery stenosis were selected as study group in the People's Hospital of Haikou from October 2015 to October 2016,and 54 patients with T2DM only were selected as control group at the same time. General information,laboratory examination results,genotypes and allele distribution frequencies were compared between the two groups,influencing factors of coronary artery stenosis in elderly patients with T2DM were analyzed by multivariate Logistic regression analysis;Gensini score and number of coronary artery lesions in elderly T2DM patients complicated with coronary artery stenosis with different genotypes were compared,and correlations of genotypes with Gensini score and number of coronary artery lesions in elderly T2DM patients complicated with coronary artery stenosis were analyzed by Spearman rank correlation analysis. Results (1)There was no statistically significant difference in gender,age,BMI,smoking rate,serum level of TC,TG,LDL-C,HDL-C or FIB between the two groups(P>0.05);drinking volume in study group was statistically significantly greater than that in control group,and incidence of blush reaction after drinking in study group was statistically significantly higher than that in control group(P<0.05).(2)There were statistically significant differences in genotypes and allele distribution frequencies between the two groups(P<0.05).(
作者 吴和弟 许丽娃 吉家钗 陈训春 王少津 WU Hedi;XU Liwa;JI Jiachai;CHEN Xunchun;WANG Shaojin(Department of Geriatrics,the People's Hospital of Haikou,Haikou 570208,China)
出处 《实用心脑肺血管病杂志》 2019年第1期53-57,共5页 Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金 海南省自然科学基金资助项目(20158337).
关键词 糖尿病 2型 冠状动脉狭窄 ALDH2基因G487A位点 多态性 多核苷酸 GENSINI积分 Diabetes mellitus,type 2 Coronary stenosis G487A locus of ALDH2 gene Polymorphism, polynucleotide Gensini integral
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