Objective To evaluate the differential diagnostic value of CT in benign and malignant thyroid nodules. Methods The CT and clinical data of 204 cases of thyroid calcification nodules confirmed by pathology from January 2013 to December 2016 were retrospectively analyzed. According to the calcification morphology, 204 cases were divided into fine granular calcification group and coarse granular calcification group. According to the location of calcification in the nodule, 204 cases were divided into central group and marginal group. Calcification morphology, calcification location and their combination in benign and malignant nodules were statistically analyzed by χ2 test. Results The calcification morphology and calcification location of benign and malignant nodules were statistically significant (P < 0.05), and their combination was also statistically significant (P < 0.05). The sensitivity of thyroid malignant nodules diagnosed by fine granular calcification and central location as standard was [81.3%(26/32), 95% CI: 67.0, 95.5%], and specificity of those was [89.3%(50/56), 95% CI: 80.9, 97.6%];the sensitivity of diagnosis of benign thyroid nodules diagnosed by coarse granular calcification and margin location as standard was [80.4%(45/56), 95% CI: 69.6, 91.1%], and specificity of those was [90.6%(29/32), 95% CI: 79.9,101.3%]. Conclusions Calcifications in the thyroid nodule fine-grained and centrally located are important signs of CT diagnosis of malignant thyroid nodules, while calcifications in the thyroid nodule coarse-grained and located at the edge of the thyroid are important signs of benign thyroid nodules.
China Journal of Modern Medicine