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血清铁蛋白、转铁蛋白、层粘连蛋白水平与肝硬化Child-Pugh分级的相关性分析 预览

Correlation Between Serum Ferritin,Transferrin,Laminin Levelsand Child-Pugh Grading of Cirrhosis
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摘要 目的分析血清铁蛋白、转铁蛋白与肝硬化Child-Pugh分级的相关性。方法130例肝硬化患者作为观察组,同期入院行健康体检者40例作为对照组,比较两组血清铁蛋白、转铁蛋白、层粘连蛋白水平。比较不同Child-Pugh分级肝硬化患者血清铁蛋白、转铁蛋白水平。分析血清铁蛋白、转铁蛋白、层粘连蛋白与肝硬化Child-Pugh评分的相关性。结果观察组血清SF、LN水平显著高于对照组,血清TRF水平显著低于对照组(P<0.05)。Child-PughA级患者血清SF、LN、Child-Pugh评分显著低于Child-PughB级、Child-PughC级患者。Child-PughA级患者血清TRF水平显著高于Child-PughB级、Child-PughC级患者。Child-PughB级患者血清SF、LN、Child-Pugh评分显著低于Child-PughC级患者。Child-PughB级患者血清TRF水平显著高于Child-PughC级患者(P<0.05)。血清铁蛋白、层粘连蛋白水平与Child-Pugh评分呈线性正相关。血清转铁蛋白含量与Child-Pugh评分呈线性负相关(P<0.05)。结论SF、TRF、LN与肝硬化程度密切相关,也与肝脏储备功能有关,检测血清SF、TRF、LN水平可对肝硬化病情进展及肝硬化的鉴别诊断提供指导。 Objective To analyze the correlation between serum ferritin(SF),transferring(TRF),laminin(LN)levels and Child-Pugh grading of cirrhosis. Methods 130 cases of patients with cirrhosis were enrolled in the observation group.40 cases of healthy examiners who were admitted to the hospital at the same time were also selected as the control group.Serum ferritin,transferrin and laminin levels were compared between the two groups.Serum ferritin,transferrin,and LN levels were compared among cirrhosis patients with different Child-Pugh grades.The correlation between serum ferritin,transferrin,LN and cirrhosis Child-Pugh score was then analyzed. Results The serum SF,LN levels in the observation group was significantly higher than that in the control group while the serum TRF level was significantly lower than that in the control group( P <0.05).The serum levels of SF and LN in Child-Pugh grade A patients were significantly lower than those of Child-Pugh grade B and Child-Pugh grade C patients.The serum TRF level of Child-Pugh grade A patients was significantly higher than that of Child-Pugh grade B and Child-Pugh grade C patients.The serum levels of SF and LN in Child-Pugh grade B patients were significantly lower than those of Child-Pugh grade C patients.Serum TRF level of Child-Pugh grade B patients was significantly higher that of Child-Pugh grade C patients( P <0.05).Serum ferritin and LN levels were linearly positively correlated with Child-Pugh score.Serum transferrin level was linearly negatively correlated with Child-Pugh score( P <0.05). Conclusion Serum levels of SF TRF and LN are closely related to the degree of liver cirrhosis,and also related to the liver reserve function.Detection of serum SF,TRF and LN levels can provide guidance for the disease progression and differential diagnosis of liver cirrhosis.
作者 江海燕 JIANG Hai-yan(Department of Clinical Laboratory,West China Guang′an Hospital,Sichuan University,Guang′an 638000,China)
出处 《标记免疫分析与临床》 CAS 2019年第2期285-289,共5页 Labeled Immunoassays and Clinical Medicine
关键词 血清铁蛋白 转铁蛋白 肝硬化 CHILD-PUGH分级 Serum ferritin Transferrin Cirrhosis Child-Pugh grading
作者简介 江海燕(1987—),女,大学本科,检验技师。Tel:18728666105;E-mail:stds2966783fujih@163.com.
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