Objective To analyze the correlation between serum ferritin(SF),transferring(TRF),laminin(LN)levels and Child-Pugh grading of cirrhosis. Methods 130 cases of patients with cirrhosis were enrolled in the observation group.40 cases of healthy examiners who were admitted to the hospital at the same time were also selected as the control group.Serum ferritin,transferrin and laminin levels were compared between the two groups.Serum ferritin,transferrin,and LN levels were compared among cirrhosis patients with different Child-Pugh grades.The correlation between serum ferritin,transferrin,LN and cirrhosis Child-Pugh score was then analyzed. Results The serum SF,LN levels in the observation group was significantly higher than that in the control group while the serum TRF level was significantly lower than that in the control group( P <0.05).The serum levels of SF and LN in Child-Pugh grade A patients were significantly lower than those of Child-Pugh grade B and Child-Pugh grade C patients.The serum TRF level of Child-Pugh grade A patients was significantly higher than that of Child-Pugh grade B and Child-Pugh grade C patients.The serum levels of SF and LN in Child-Pugh grade B patients were significantly lower than those of Child-Pugh grade C patients.Serum TRF level of Child-Pugh grade B patients was significantly higher that of Child-Pugh grade C patients( P <0.05).Serum ferritin and LN levels were linearly positively correlated with Child-Pugh score.Serum transferrin level was linearly negatively correlated with Child-Pugh score( P <0.05). Conclusion Serum levels of SF TRF and LN are closely related to the degree of liver cirrhosis,and also related to the liver reserve function.Detection of serum SF,TRF and LN levels can provide guidance for the disease progression and differential diagnosis of liver cirrhosis.
Labeled Immunoassays and Clinical Medicine