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黄体酮补充时机对曲唑诱排供精人工授精妊娠结局的影响 预览

Best time for progesterone supplementation in aid ovulation induction cycles by letrozole
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摘要 目的:研究黄体酮补充时机对来曲唑诱导排卵供精人工授精妊娠结局的影响。方法:本研究选取在生殖中心进行供精人工授精的509名患者,用来曲唑诱排卵,根据排卵后补充黄体酮的时间随机分成4组:排卵后72h补充黄体酮为组1,排卵后48h补充黄体酮为组2,排卵后24h补充黄体酮为组3,未补充黄体酮为组4。通过监测人工授精后14天B超及HCG值评估黄体酮补充时机对妊娠结局的影响。结果:排卵后72h补充黄体酮的妊娠率为31.9%,显著高于其它各组(31.9%vs.19.3%,18.0%,11.4%,P均<0.05),补充黄体酮组妊妊娠率显著高于未补充组(31.9%,19.3%,18.0%vs.11.4%,P<0.05),未补充组足月分娩率显著性低于排卵后72h补充黄体酮组(61.1%vs.89.2%,P<0.05),四组流产率比较无统计学差异(P>0.05)。结论:供精人工授精中,来曲唑诱排卵后72h补充黄体酮能显著提高患者妊娠率,且不增加患者流产率。 Objective:To explore the best time for progesteronesupplementation in AIDusing Letrozole for ovulationinduction.Methods:A total of 509 patients who undersentArtificial Insemination by Donor(AID)usingletrozole(LE)for ovulationinduction between August 2014 and July 2015 were enrolled in this study.All patients wererandomly divided into1 control group(group 4,no progesterone supplementation)and 3 experiemtalgoupsaccording to the time of progesterone supplementation group 1-3),group 1-3 was given progesterone supplementation 72h,48 h,and 24 hafter ovulation,respectively.The gestation and live birth rate were evaluated by monitoring vaginal ultrasound and HCG blood value14 days after AID.Results:The pregnancy rate in group 1was 31.9%,which was significantly higher than the other 3 groups(31.9% vs.19.3%,18.0%,11.4%,P all<0.05).The pregnancy rate of group 4 was significantly lower than the 3 experimental groups(11.4%vs.31.9%,19.3%,18.0%,P<0.05).However,there was no significant difference in the numbers of abortions among the four groups(P>0.05).Besides,the live birth rate of group 4 was significantly lower than that of group 1(61.1%vs.89.2%,P<0.05).Conclutions:Progesterone administrated72h after ovulation can promoted the gestation rate without affecting the rate of miscarrage.
作者 王雪梅 娄华 崔元戎 张霞 董波 常彩红 WANG Xue-mei;LOU Hua;CUI Yuan-rong;ZHANG Xia;DONG Bo;CHANG Cai-hong(Reproduction Research Institute,Luoyang Health Care Center for Women and Children Health Center,Luo Yang,471000,China;Reproductive Medicine Centre,the Third Affiliated Hospital of Zhengzhou University,Henan,Zhengzhou 450052,China;Hainan Medical College,HaiNan,571103,China)
出处 《海南医学院学报》 CAS 2019年第5期343-346,共4页 Journal of Hainan Medical University
基金 国家自然科学基金项目(81260124) 河南省教育厅科技攻关项目(14B310019).
关键词 孕激素 来曲唑 人工授精 地屈孕酮片 供精人工授精 Progesterone Letrozole Artificial Insemination Dydrogesterone Clomiphene Citrate Artificial Insemination by Donor(AID)
作者简介 王雪梅,电话:18638808271,E-mail:715302568@qq.com;通讯作者:常彩红(1971-),女,博士,副教授,副主任技师,主要从事生殖医学研究,E-mail:913711253@qq.com。
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