Objective: To systematically evaluate the efficacy and safety of Simiao Decoction on gout compared with colchicine,and to provide evidence-based basis for clinical treatment of gout. Methods: CNKI,Wanfang database,VIP database,PubMed,Medline,Embase database were searched by computer. Randomized controlled clinical trials(RCT) were collected to compare the efficacy(total effective rate,significant efficiency,UA of serum uric acid) and safety of colchicine(the control group) and Simiao Decoction(the experimental group) on gout. The methodological quality of the study was evaluated with the modified Jadad scale,and the valid data were extracted. Meta-analysis was carried out with RevMan 5.3 software. Results: 16 RCTs were included,involving 1 355 patients. Compared with colchicine,Simiao Decoction had certain advantages in total effective rate,marked efficiency and UA level reduction in gout treatment,with statistical significance(P < 0.05). The incidence of adverse reactions was lower than that of colchicine,with statistical significance(P < 0.05). Conclusion: Simiao Decoction has certain advantages over colchicine on gouty arthritis,and the incidence of adverse reactions is low.
Journal of Emergency in Traditional Chinese Medicine