Objective To investigate the effect of continuous blood purification in treatment of patients with severe acute pancreatitis complicated with multiple organ dysfunction syndrome (MODS) and its influence on peripheral blood inflammatory factors. Methods A total of 50 patients with severe acute pancreatitis complicated with MODS were divided into observation group( n =33) and control group( n =17) according to the different treatment methods.The control group only took conventional treatment, while the observation group added continuous blood purification treatment.According to the data collected, the clinical hospitalization time, APACHE Ⅱ score, and serum inflammatory factors in the two groups were analyzed and compared before and after treatment. Results After active treatment, the average length of hospital stay, and APACHE Ⅱ score of two groups showed significant difference( P <0.05).The peripheral blood C-reactive protein (CRP), interleukin-6(IL-6), interleukin-10(IL-10) in the observation group were lower than those in the control group( P <0.05). ConclusionContinuous blood purification for severe acute pancreatitis complicated with MODS has a good clinical effect, which can significantly reduce the level of peripheral inflammatory factors, and improve the effective healing ability.
Journal of Clinical Medicine in Practice
severe acute pancreatitis
continuous blood purification
multiple organ dysfunction syndrome