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连续性血液净化对重症急性胰腺炎并发多器官功能衰竭患者的疗效及对外周血炎症因子的影响 预览

Effect of continuous blood purification on the treatment of patients with severe acute pancreatitis complicated with multiple organ dysfunction syndrome and its impact on peripheral blood inflammatory factors
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摘要 目的探讨连续性血液净化治疗重症急性胰腺炎并发多器官功能衰竭(MODS)患者的效果及其对患者外周血炎症因子的影响。方法选取本院确诊为重症急性胰腺炎并发MODS的患者50例,根据治疗方法不同将其分为观察组(n=33)和对照组(n=17)。对照组仅采取常规治疗,而观察组在对照组基础上加用连续性血液净化治疗。分析比较这2组患者的住院时间、急性生理与慢性健康(APACHEⅡ)评分、治疗前后血清炎症因的变化。结果治疗后,2组平均住院时间、APACHEⅡ评分比较差异有统计学意义(P<0.05);观察组外周血C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)和肿瘤坏死因子-α(TNF-α)水平均低于对照组,差异有统计学意义(P<0.05)。结论连续性血液净化治疗重症急性胰腺炎并发MODS患者具有良好的临床疗效,可显著降低患者外周炎症因子的水平,有效提高治愈能力。 Objective To investigate the effect of continuous blood purification in treatment of patients with severe acute pancreatitis complicated with multiple organ dysfunction syndrome (MODS) and its influence on peripheral blood inflammatory factors. Methods A total of 50 patients with severe acute pancreatitis complicated with MODS were divided into observation group( n =33) and control group( n =17) according to the different treatment methods.The control group only took conventional treatment, while the observation group added continuous blood purification treatment.According to the data collected, the clinical hospitalization time, APACHE Ⅱ score, and serum inflammatory factors in the two groups were analyzed and compared before and after treatment. Results After active treatment, the average length of hospital stay, and APACHE Ⅱ score of two groups showed significant difference( P <0.05).The peripheral blood C-reactive protein (CRP), interleukin-6(IL-6), interleukin-10(IL-10) in the observation group were lower than those in the control group( P <0.05). ConclusionContinuous blood purification for severe acute pancreatitis complicated with MODS has a good clinical effect, which can significantly reduce the level of peripheral inflammatory factors, and improve the effective healing ability.
作者 朱哲 ZHU Zhe(Emergency Department, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning, 117004)
出处 《实用临床医药杂志》 CAS 2019年第5期50-52,共3页 Journal of Clinical Medicine in Practice
关键词 重症急性胰腺炎 连续性血液净化 多器官功能衰竭 炎症因子 白细胞介素 C反应蛋白 severe acute pancreatitis continuous blood purification multiple organ dysfunction syndrome inflammatory factors interleukin C-reactive protein
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