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更昔洛韦治疗儿童传染性单核细胞增多症的临床疗效 预览

Clinical efficacy of ganciclovir in the treatment of infectious mononucleosis in children
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摘要 目的探讨更昔洛韦治疗儿童传染性单核细胞增多症的临床效果。方法选取80例传染性单核细胞增多症患儿随机分为2组,更昔洛韦组给予更昔洛韦治疗,干扰素组则给予干扰素雾化治疗,比较2组患儿各临床症状缓解时间、总体治疗效果、实验室指标、不良反应与随访结果。结果更昔洛韦组患儿各临床症状缓解时间显著早于干扰素组,总有效率显著高于干扰素组(P<0.05);治疗后,更昔洛韦组异型淋巴细胞比例(ALY%)、谷丙转氨酶(ALT)与CD8^+水平均显著低于干扰素组,CD4^+与CD4^+/CD8^+水平显著高于干扰素组(P<0.05);更昔洛韦组治疗后复查白细胞(WBC)>20×10^9/L与ALY%>10%者占比均显著低于干扰素组(P<0.05);2组患儿治疗期间药物不良反应发生率无显著差异(P>0.05)。结论相较于干扰素雾化治疗方式,更昔洛韦治疗儿童传染性单核细胞增多症的临床疗效更优。 Objective To investigate the clinical efficacy of ganciclovir in the treatment of infectious mononucleosis in children. Methods A total of 80 children with infectious mononucleosis admitted to our hospital were randomly divided into two groups. Children in ganciclovir group were treated with ganciclovir and those in interferon group were treated with interferon atomization. The time to clinical symptoms relief, overall therapeutic effect, laboratory indicators, adverse reactions and follow-up results of the two groups were compared. Results The remission time of clinical symptoms in ganciclovir group was significantly lower, the total effective rate was significantly higher than that in interferon group( P <0.05). After treatment, the proportion of atypical lymphocyte(ALY%), the level of glutamic-pyruvic transaminase(ALT) and CD8 + were significantly lower, and the levels of CD4^+ and CD4^+/CD8^+ were significantly higher than that in interferon group( P <0.05). After treatment, the proportion of patients with white blood cell (WBC)>20×10^9/L and ALY%>10%in ganciclovir group was significantly lower than that of interferon group ( P <0.05), but there was no significant difference in adverse drug reactions between the two groups ( P >0.05). Conclusion Compared with interferon nebulization therapy, ganciclovir treatment for infectious mononucleosis in children has more significant clinical efficacy.
作者 李瑞娜 刘小乖 雷玲侠 舒畅 彭晓康 刘攀 刘希 李亚绒 LI Ruina;LIU Xiaoguai;LEI LingxiaSHU Chang;PENG Xiaokang;LIU Pan;LIU Xi;LI Yarong(Department of Pediatrics,Xi′an Children′s Hospital,Xi′an,Shaanxi710000)
出处 《实用临床医药杂志》 CAS 2019年第6期96-99,共4页 Journal of Clinical Medicine in Practice
基金 陕西省卫生厅科研基金项目(2016D1670).
关键词 更昔洛韦 干扰素 传染性单核细胞增多症 随访 ganciclovir ribavirin infectious mononucleosis follow-up
作者简介 通信作者:李亚绒.
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