Objective To investigate the clinical efficacy of ganciclovir in the treatment of infectious mononucleosis in children. Methods A total of 80 children with infectious mononucleosis admitted to our hospital were randomly divided into two groups. Children in ganciclovir group were treated with ganciclovir and those in interferon group were treated with interferon atomization. The time to clinical symptoms relief, overall therapeutic effect, laboratory indicators, adverse reactions and follow-up results of the two groups were compared. Results The remission time of clinical symptoms in ganciclovir group was significantly lower, the total effective rate was significantly higher than that in interferon group( P <0.05). After treatment, the proportion of atypical lymphocyte(ALY%), the level of glutamic-pyruvic transaminase(ALT) and CD8 + were significantly lower, and the levels of CD4^+ and CD4^+/CD8^+ were significantly higher than that in interferon group( P <0.05). After treatment, the proportion of patients with white blood cell (WBC)>20×10^9/L and ALY%>10%in ganciclovir group was significantly lower than that of interferon group ( P <0.05), but there was no significant difference in adverse drug reactions between the two groups ( P >0.05). Conclusion Compared with interferon nebulization therapy, ganciclovir treatment for infectious mononucleosis in children has more significant clinical efficacy.
Journal of Clinical Medicine in Practice