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脾胃气虚型化疗患者应用四君子汤加味治疗临床效果分析及对患者QOL评分影响

Research on the Clinical Effect of Modified Sijunzi Decoction and Its Effect on QOL Score of Patients with Spleen and Stomach Qi Deficiency Type Chemotherapy
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摘要 目的:探究脾胃气虚型化疗患者应用四君子汤加味治疗的临床效果分析及对患者QOL评分的影响。方法:选取2016年8月-2018年2月期间我院收治的脾胃气虚型化疗患者100例作为研究对象,采用随机数字方法进行分组,对照组50例给予高选择性5-羟色胺3(5-HT3)受体拮抗药盐酸托烷司琼,观察组50例在对照组基础上给予四君子汤加味治疗,对比两组治疗效果。结果:观察组、对照组的治疗总有效率分别为96.00%(48/50)、84.00%(42/50),对比差异明显(P<0.05);治疗后观察组生活质量QOL评分(58.58±5.28)分明显优于对照组(38.96±4.69)分(P<0.05)。治疗前,两组CD4^+、CD8^+、CD4^+/CD8^+水平等相关指标对比无显著差异(P>0.05);治疗后,观察组免疫功能明显优于对照组(P<0.05)。观察组恶心呕吐不良反应程度及持续时间等指标明显优于对照组(P<0.05)。结论:脾胃气虚型化疗患者应用四君子汤加味治疗,能够有效改善患者生存质量及免疫功能,改善呕吐及恶心情况,具有较高的临床价值。 Objective:To explore the clinical effect of Modified Sijunzi Decoction on QOL score of patients with spleen and stomach Qi deficiency chemotherapy. Methods:Selected August 2016-February 2018 our hospital during the period of spleen and stomach Qi deficiency type chemotherapy in patients with 100 cases as the research object,used the method of random numbers to observation group and control group. The control group of 50 cases was given highly selective serotonin 3(5-HT3)receptor antagonist medicine tropisetron hydrochloride Siqiong,observation group of 50 cases was given Modified Sijunzi Decoction on the basis of the control group,compared two groups of therapeutic effect.Results:The total effective rate of the observation group and the control group was 96.00%(48/50)and84.00%(42/50)respectively,with significant difference(P<0.05). After treatment,QOL score of the observation group(58.58±5.28)points was significantly better than that of the control group(38.96±4.69)points(P<0.05). Before treatment,there was no significant difference in CD4^+,CD8^+,CD4^+/CD8^+levels between the two groups(P>0.05). After treatment,the immune function of the observation group was significantly better than that of the control group(P<0.05). The adverse reaction degree and duration of nausea and vomiting in the observation group were significantly better than those in the control group(P<0.05). Conclusion:Chemotherapy patients with spleen and stomach Qi using Modified Sijunzi Decoction deficiency type treatment,can effectively improve the patients’ life quality and immune function,improve the vomiting and nausea,has high clinical value.
作者 吴明松 李姗姗 李通捷 梁莉莉 周玉球 孙玉霞 潘宗奇 WU Mingsong;LI Shanshan;LI Tongjie;LIANG Lili;ZHOU Yuqiu;SUN Yuxia;PAN Zongqi(Wuzhou Hospital of Traditional Chinese Medicine,Wuzhou 543002,Guangxi,China;Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510000,Guangdong,China)
出处 《辽宁中医药大学学报》 CAS 2019年第3期99-102,共4页 Journal of Liaoning University of Traditional Chinese Medicine
基金 广西中医药民族医药科研项目(GZZC16-90).
关键词 脾胃气虚型化疗 四君子汤加味 临床疗效 QOL评分 spleen and stomach Qi deficiency type chemotherapy Modified Sijunzi Decoction clinical effect QOL scores
作者简介 吴明松(1981-),男,广西贵港人,副主任医师,硕士研究生,研究方向:中西医结合肿瘤;通讯作者:潘宗奇(1981-),男,广东湛江人,副主任医师,硕士,研究方向:中西医结合肿瘤。
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