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牙周炎伴糖尿病病人龈沟液中炎症因子MCP-1、TNF-α、IL-6的水平及其临床意义 预览

LEVELS OF INFLAMMATORY CYTOKINES MONOCYTE CHEMOATTRACTANT PROTEIN-1,TUMOR NECROSIS FACTOR-α,AND INTERLEUKIN-6 IN GINGIVAL CREVICULAR FLUID OF PATIENTS WITH PERIODONTITIS AND DIABETES AND THEIR CLINICAL SIGNIFICANCE
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摘要 目的探讨牙周炎伴2型糖尿病病人龈沟液中炎症因子单核细胞趋化蛋白-1(MCP-1)、肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)的水平及其临床意义。方法 选取研究对象159例,其中牙周炎伴2型糖尿病组(B组)46例,2型糖尿病组(C组)40例,单纯牙周炎组(D组)34例和健康对照组(A组)39例,收集研究对象的龈沟液,应用ELISA法检测所有龈沟液中MCP-1、TNF-α和IL-6的水平。并采用析因设计方差分析分析牙周炎与2型糖尿病的相互影响。结果 B、C和D组龈沟液中MCP-1、TNF-α和IL-6浓度均明显高于A组,差异均有统计学意义(F=480.860~2303.362、P<0.05)。进一步分析糖尿病和牙周炎的单独效应,结果显示,牙周炎可单独引起MCP-1、TNF-α、IL-6的升高,糖尿病可协同牙周炎引起3种炎症因子的升高。结论 2型糖尿病与牙周炎间相互促进,两者并发易使牙周炎病人症状加重。 Objective To investigate the levels of inflammatory cytokines monocyte chemoattractant protein-1(MCP-1),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)in the gingival crevicular fluid of patients with periodontitis and type 2 diabetes and their clinical significance.Methods A total of 159 subjects were enrolled,among whom 39 were healthy indivi-duals(group A),46 had periodontitis and type 2 diabetes(group B),40 had type 2 diabetes alone(group C),and 34 had periodontitis alone(group D).Gingival crevicular fluid was collected,and ELISA was used to measure the levels of MCP-1,TNF-α,and IL-6.A factorial analysis of variance was used to analyze the interaction between periodontitis and type 2 diabetes.Results Groups B,C,and D had significantly higher concentrations of MCP-1,TNF-α,and IL-6 in gingival crevicular fluid than group A(F=480.860-2 303.362,P<0.05).Further analysis of the individual effect of diabetes and periodontitis showed that periodontitis independently caused the increases in MCP-1,TNF-α,and IL-6,and diabetes in combination with periodontitis induced the increases in the above inflammatory factors.Conclusion Type 2 diabetes and periodontitis promote each other,and a combination of these two diseases can aggravate the symptoms of patients with periodontitis.
作者 朱靖 刘桂荣 吕晔 赵婧 荆冉 徐晓娜 陈书兰 ZHU Jing;LIU Guirong;LYU Ye;ZHAO Jing;JING Ran;XU Xiaona;CHEN Shulan(School of Stomatology,Weifang Medical University,Weifang 261021,China)
出处 《精准医学杂志》 2019年第1期67-70,共4页 Journal of Precision Medicine
基金 山东省医药卫生科技发展计划项目(2017WS310).
关键词 牙周炎 糖尿病 2型 趋化因子CCL2 肿瘤坏死因子α 白细胞介素6 Periodontitis Diabetes mellitus,type 2 Chemokine CCL2 Tumor necrosis factor-alpha Interleukin-6
作者简介 通讯作者:陈书兰,Email:chenshulanqd@126.com.
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