目的:将富血小板纤维蛋白(advanced platelet-rich fibrin, A-PRF)膜应用于前庭沟加深术,探讨其促进种植体周附着龈再生的临床效果。方法:收集2015年10月─2017年7月在本院因种植体周附着龈不足而需前庭沟加深术的患者共26例,运用统计学中简单随机方法将患者随机分为2组(n=13),实验组应用A-PRF膜,对照组仅采用常规手术。术后不同时间点对附着龈再生、黏膜状态、疼痛程度进行评价。采用SPSS 17.0软件包对数据进行统计学分析。结果:术后2周、12周,实验组新增附着龈分别为(3.15±0.36)mm和(2.81±0.36)mm,均显著高于对照组的(2.93±0.29)mm和(2.52±0.30)mm(P<0.05)。实验组术后黏膜愈合状态也显著优于对照组(P<0.05)。实验组术后3 d疼痛程度为(51.03±12.20)分,与对照组(58.22±9.86)分比较显著降低(P<0.05)。结论:A-PRF膜应用于前庭沟加深术可有效促进创口愈合,缓解术后疼痛,并增加种植体周附着龈再生。
PURPOSE: Advanced platelet-rich fibrin(A-PRF) was applied in vestibular extension surgery to explore its effect on promoting regeneration of attached gingival around dental implants. METHODS: Twenty-six patients with insufficient attached gingiva around dental implants were enrolled in this study from October 2015 to July 2017, they were randomly divided into two groups(n =13). The experimental group received vestibular extension surgery with A-PRF membrane covering the wound, while the control group only received routine surgery. Increase of attached gingival, mucosa healing status and pain intensity were evaluated at different time points after surgery. SPSS 17.0 software package was used for statistical analysis. RESULTS: In the experimental group, increase of attached gingival at 2 and 12 weeks was(3.15±0.36) mm and(2.81±0.36) mm respectively, which was significantly higher than those [(2.93 ±0.29) mm and(2.52±0.30) mm] in the control group(P<0.05). The mucosa healing status in the experimental group at 2 and 12 weeks was also significantly better than that in the control group(P<0.05). Visual analogue scale(VAS) of pain in the experimental group was 51.03±12.20, which was significantly lower than that(58.22±9.86) in the control group(P<0.05). CONCLUSIONS:Application of A-PRF membrane in vestibular extension surgery could effectively promote mucosa healing, relieve postoperative pain and increase attached gingival regeneration around dental implants.
China Journal of Oral and Maxillofacial Surgery
Advanced platelet-rich fibrin
Vestibular extension surgery