Objective:To investigate the effects of noninvasive mechanical ventilation vs.nasal high flow oxygen therapy following extubation on the blood gas index in acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:122 cases of AECOPD were selected as the research objects,and divided into observation group and control group with 61 cases in each group according to the order of admission and the principle of random envelope drawing.The control group was given the noninvasive mechanical ventilation treatment,and the observation group was given nasal high flow oxygen therapy after extubation.The effectiveness and the blood gas changes were recorded in the two groups.Results:After treatment,the total effective rate in the observation group and the control group was 98.3%and 88.5%respectively(P<0.05).After treatment,the PaO2 values in the two groups increased significantly,and PaCO2 values were decreased significantly(P<0.05),and there was significant difference in PaO2 and PaCO2 values between two groups(P<0.05).After treatment,FVC and FEV1 values in both groups were significantly higher than those before treatment(P<0.05),and those in the observation group after treatment were also significantly higher than in the control group(P<0.05).The ventilator use time and length of hospital stay in the observation group were significantly shorter than those in the control group(P<0.05).There was no significant difference in abdominal distension,nose injury and other complications between two groups(P>0.05).Conclusion:The nasal high flow oxygen therapy after extubation in the treatment of AECOPD can improve the blood gas index,lung function and the overall treatment effects,promote the rehabilitation of patients,and will not increase the complications.
Journal of Internal Intensive Medicine
Noninvasive mechanical ventilation
High flow oxygen therapy
Chronic obstructive pulmonary disease
Blood gas index