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上段输尿管尿路上皮细胞癌患者预后的影响因素分析 预览

Prognostic factors of upper tract urothelial carcinoma
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摘要 目的探讨上段输尿管尿路上皮细胞癌患者预后的影响因素。方法依据预后评估结果,133例上段输尿管尿路上皮细胞癌患者中,预后不佳组56例,预后良好组77例。上段输尿管尿路上皮细胞癌患者预后的影响因素采用Logistic逐步回归分析。结果单因素分析结果显示,不同肿块数目、肿瘤直径、病理分级、临床分期、合并慢性肾脏病情况和膀胱灌注化疗情况上段输尿管尿路上皮细胞癌患者的预后情况比较,差异均有统计学意义(P﹤0.05)。Logistic回归分析结果显示,合并慢性肾脏病、肿瘤直径≥3cm、病理分级为G3级、临床分期为Ⅱ~Ⅲ期、未接受膀胱灌注化疗均是影响上段输尿管尿路上皮细胞癌患者预后的独立危险因素。结论合并慢性肾脏病、肿瘤直径≥3cm、病理分级为G3级、临床分期为Ⅱ~Ⅲ期、未接受膀胱灌注化疗均是影响上段输尿管尿路上皮细胞癌患者预后的独立危险因素。 Objective To express the factors influencing the prognosis of upper tract urothelial carcinoma.Method According to the prognostic evaluation results,among 133 cases of upper ureteral urothelial cell carcinoma,56 cases had poor prognosis and 77 cases had good prognosis.The factors influencing the prognosis of patients with upper tract urothelial carcinoma were analyzed using Logistic regression analysis.Result Univariate analysis showed that there were significant differences in the number of tumors,diameter of tumors,pathological grade,clinical stage,complication with chronic kidney disease and prognosis of upper ureteral urothelial cell carcinoma patients treated with intravesical instillation chemotherapy (P<0.05).In Logistic regression analysis,combined chronic kidney disease,tumor diameter ≥3 cm, pathological classification of G3,clinical stage of Ⅱ-Ⅲ and no history of intravesical instillation were independent risk factors for upper tract urothelial carcinoma.Conclusion The independent risk factors for prognosis of patients with upper tract urothelial carcinoma includes combined chronic kidney disease,tumor diameter ≥3 cm,pathological classification of G3,clinical stage of Ⅱ-Ⅲ,and no history of intravesical instillation chemotherapy.
作者 徐惠丽 韩永红 王纯 卢驰 曾娟 XU Huili;HAN Yonghong;WANG Chun;LU Chi;ZENG Juan(Department of Oncology,the Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430014,Hubei,China)
出处 《癌症进展》 2019年第7期856-858,共3页 Oncology Progress
关键词 上段输尿管 尿路上皮癌 预后 影响因素 upper tract urothelial carcinoma prognosis risk factors
作者简介 通信作者(corresponding author):徐惠丽,邮箱:xianzhi407894@163.com.
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