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曲妥珠单抗联合DS化疗方案对HER-2阳性晚期胃癌患者的影响 预览

Effect of Trastuzumab Combined with DS Chemotherapy on HER-2 Positive Advanced Gastric Cancer Patients
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摘要 目的分析曲妥珠单抗联合DS化疗方案对人表皮生长因子受体2(HER-2)阳性晚期胃癌患者血清肿瘤标志物及功能状态(KPS评分)影响。方法选取2016年9月~2018年4月本院HER-2阳性晚期胃癌患者62例,按治疗方法不同分为联合组(n=31)与DS组(n=31)。DS组给予DS化疗方案治疗,联合组在DS组基础上接受曲妥珠单抗治疗,观察对比两组治疗前后糖类抗原199(CA199)、癌胚抗原(CEA)、胃癌抗原(CA724)及KPS评分。结果治疗后联合组KPS评分高于DS组;治疗后联合组血清CA199、CEA、CA724水平较DS组低,组间比较差异均有统计学意义(P<0.05)。结论曲妥珠单抗联合DS化疗方案应用于HER-2阳性晚期胃癌患者,可降低血清CA724、CA199、CEA水平,提高生存质量。 Objective To analyze the effect of Trastuzumab combined with DS chemotherapy on serum tumor markers and functional status (KPS rating) of advanced gastric cancer patients with positive human epidermal growth factor receptor 2(HER-2). Methods 62 patients with HER-2 positive advanced gastric cancer from September 2016 to April 2018 were selected and divided into combined group (n=31) and DS group (n=31) according to different treatment Methods. DS group was treated with DS chemotherapy, while combined group was treated with Trastuzumab on the basis of DS group. The carbohydrate antigen 199 (CA199), carcinoembryonic antigen (CEA), gastric cancer antigen (CA724) and KPS scores before and after treatment were observed and compared between the two groups. Results KPS score of combined group was higher than DS group after treatment. After treatment, the levels of serum CA199, CEA and CA724 in the combined group were lower than those in the DS group, and the differences between the groups were statistically significant (P < 0.05). Conclusion The application of Trastuzumab combined with DS chemotherapy in HER-2 positive advanced gastric cancer patients can reduce serum CA724, CA199 and CEA levels and improve the quality of life.
作者 吴洁清 WU Jie-qing(Department of Oncology, First Affiliated Hospital of Xinxiang Medical University, Henan, Xinxiang, 453000, China)
出处 《临床研究》 2019年第5期7-8,共2页 Clinical Research
关键词 曲妥珠单抗 DS化疗方案 HER-2阳性晚期胃癌 血清肿瘤标志物 KPS评分 trastuzumab DS chemotherapy scheme HER-2 positive advanced gastric cancer serum tumor markers KPS rating
作者简介 吴洁清(1966-),男,汉族,河南新乡人,副主任医师,本科。研究方向:肿瘤治疗.
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