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氯己定漱口液配合口腔正畸治疗牙周病致前牙移位的疗效及对患者血清IL-2 IL-6 TNF-α水平的影响 预览

Effect of Chlorhexidine Gargle combined with Orthodontic treatment on Anterior Teeth Displacement caused by Periodontal Disease and its Influence on Serum Levels of IL-2 IL-6 and TNF-alpha
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摘要 目的:探讨氯己定漱口液配合口腔正畸对牙周病致前牙移位的疗效及对患者血清白细胞介素(IL)-2、IL-6、肿瘤坏死因子(TNF)-α水平的影响。方法:选取我院2015年1月至2018年1月收治的108例牙周病致前牙移位患者,采用简单随机数字表法分为两组。对照组(54例)予以口腔正畸治疗,观察组(54例)在此基础上加用氯己定漱口液治疗。比较两组临床疗效,治疗前后牙周指标及血清IL-2、IL-6、TNF-α水平变化,不良反应发生情况。结果:治疗12个月后,观察组总有效率为94.4%,较对照组明显升高(81.5%,P<0.05)。两组治疗12个月后牙周指标探诊出血率、前牙覆盖、牙周袋深度值及血清IL-6、TNF-α水平较治疗前均显著下降(P<0.01),且观察组上述指标降低更显著(P<0.01)。与治疗前对比,两组治疗12个月后血清IL-2水平显著上升(P<0.01);且与对照组同期相比,观察组治疗后血清IL-2水平显著更高(P<0.01)。与对照组(13.0%)比较,观察组不良反应率为9.3%,差异无统计学意义(P>0.05)。结论:牙周病致前牙移位应用氯己定漱口液配合口腔畸形治疗更能有效调节患者机体炎性细胞因子水平,改善牙周状态,临床疗效显著。 Objective: To investigate the effect of chlorhexidine gargle combined with orthodontic treatment on anterior teeth displacement caused by periodontal disease and the effects of chlorhexidine gargle on serum levels of interleukin-2, interleukin-6 and tumor necrosis factor-alpha. Methods: 108 patients with anterior teeth displacement caused by periodontal disease were selected from January 2015 to January 2018 in our hospital. They were divided into two groups by simple random number table. The control group (54 cases) was treated with orthodontic treatment, while the observation group (54 cases) was treated with chlorhexidine mouthwash. The clinical efficacy, periodontal indexes, serum levels of IL-2, IL-6 and TNF-alpha, and adverse reactions were compared between the two groups before and after treatment. Results: After receiving treatment for 12 months, overall effective rate of observation group was 94.4% which was significant higher than control group's 81.5%(P<0.05). After receiving treatment for 12 months, Two groups' periodontal index including probing bleeding rate, anterior teeth covering, periodontal pocket depth values and serum IL-2, IL-6 and TNF-α decreased significantly if comparing with those before treatment (P<0.01), and observation group's above index decreased more significantly (P<0.01). Serum IL-2 of two groups' increased significantly after receiving treatment for 12 months if comparing with that before treatment (P<0.01). Observation group's serum IL-2 was significant higher after treatment if comparing with control group at same time (P<0.01). There was no statistical significance if comparing control group adverse reaction rate (13.0%) with observation group's (9.3%)(P>0.05). Conclusion: The treatment of anterior teeth displacement caused by periodontal disease with chlorhexidine mouthwash combined with oral malformation can effectively regulate the level of inflammatory cytokines in patients, improve periodontal status and have significant clinical effects.
作者 张小玉 虞宝中 田丽 ZHANG Xiaoyu;TIAN Li(The First People's Hospital of Guangyuan, Sichuan Guangyuan 628017, China)
出处 《河北医学》 CAS 2019年第4期575-579,共5页 Hebei Medicine
基金 四川省科研课题项目,(编号:120234).
关键词 前牙移位 氯己定漱口液 口腔正畸 白细胞介素-2 白细胞介素-6 肿瘤坏死因子-α Anterior teeth displacement Chlorhexidine gargle Interleukin-2 Interleukin-6 Tumor necrosis factor-α
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