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陈皮炮制前后挥发性化学成分变化及炮制理论分析

Changes of Volatile Chemical Composition Before and after Processing of Chenpi and Its Theoretical Analysis
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摘要 目的:探究陈皮炮制前及炮制后挥发性化学成分改变状况,为分析其炮制原理提供一些借鉴。方法:依据《中国药典》内水蒸气蒸馏法对生品陈皮炮制前后其挥发油进行提取,同时气相色谱-质谱(GC-MS)对挥发油内化学成分行对比分析。结果:蒸制以后陈皮内挥发油含量下降,从生品含量1.13%下降到1.06%,制陈皮内检出峰30个,有24种可鉴定物质;生品陈皮内检出峰33个,有24种可鉴定化合物。蒸制前及蒸制后都有的为15种,蒸制后有9种为新检出的,有9种没有检出。陈皮炮制前后都有化合物中,相对含量下降的有10种,相对含量增大的有4种,其中增加最显著的为柠檬烯,由炮制前68.790%上升至炮制后的76.925%。结论:生品陈皮蒸制前后其发挥有内化学成分发生改变,其含量和组分都出现了变化,为临床应用和探究陈皮炮制以后其药性变化提供了一些新的借鉴。 Objective: To explore the changes of volatile chemical constituents before and after processing,and provide some references for analyzing the processing principle. Methods: According to the Chinese Pharmacopoeia,the volatile oil was extracted before and after the processing of raw tangerine peel by gas steam distillation. The chemical constituents of volatile oil were analyzed by gas chromatography-mass spectrometry(GC-MS). Results: After steaming,the content of volatile oil in dried tangerine peel decreased from 1.13% of raw product to 1.06%. There were 30 peaks in the tangerine peel and 24 identifiable substances. There were 33 peaks in the dried tangerine peel. An identifiable compound. There were 15 kinds before steaming and after steaming. After steaming,9 kinds were newly detected,and 9 kinds were not detected. There were 10 kinds of compounds in the compound before and after processing. There were 4 kinds of relative content decreased,and 4 kinds of relative content increased. The most significant increase was limonene,which increased from 68.790% before processing to 76.925% after processing. Conclusion: There are changes in the internal chemical composition of the dried tangerine peel before and after steaming,and its content and composition have changed. It provides some new references for clinical application and exploration of its drug changes after the processing of tangerine peel.
作者 姜琼 张雄 李雪莲 庞雷红 郑琰 JIANG Qiong;ZHANG Xiong;Li Xuelian(Department of Pharmacy of Traditional Chinese Medicine,Wangxian Hospital of Traditional Chinese Medicine of Dayi,Dayi Sichuan 6113302,China)
出处 《四川中医》 2019年第3期71-73,共3页 Journal of Sichuan of Traditional Medicine
基金 四川省2014年度第一批省级科技计划项目(编号:2014SZ0071).
关键词 陈皮 挥发油 炮制 气相色谱-质谱 Tangerine peel Volatile oil Processing Gas chromatography-mass spectrometry
作者简介 通讯作者:郑琰,成都中医药大学附属医院药剂科,本科,主任药师,从事医院制剂研究及临床药学。
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