目的分析高频振荡通气(HFOV)联合肺表面活性物质(PS)治疗新生儿肺出血(NPH)的效果。方法选择本院2015年2月至2018年9月收治的NPH患儿46例为研究对象,根据入院顺序奇偶性分为对照组(n=23)和研究组(n=23)。对照组采用HFOV进行治疗,研究组采用HFOV联合PS进行治疗。比较两组患儿的治疗效果。结果治疗后6、12、24 h,两组患儿的PaO2均显著升高,PaCO2均显著降低,且研究组优于对照组,差异具有统计学意义(P<0.05)。研究组治疗后6、12、24 h的OI值均显著低于对照组,差异具有统计学意义(P<0.05)。研究组患儿的脑出血停止时间、氧暴露时间、通气时间及住院时间均显著短于对照组,差异具有统计学意义(P<0.05)。研究组患儿的并发症总发生率显著低于对照组,治愈率显著高于对照组,差异具有统计学意义(P<0.05)。结论 HFOV联合PS治疗NPH,可有效缩短呼吸机使用时间,降低并发症发生率,安全性更高,值得借鉴。
Objective To analyze the effect of high-frequency oscillation ventilation(HFOV) combined with pulmonary surfactant(PS) on pulmonary hemorrhage of newborn(NPH). Methods Forty-six children with NPH admitted in our hospital from February 2015 to September 2018 were selected as the study objects and divided into control group(n=23)and study group(n=23) according to the parity of admission sequence. The control group was treated with HFOV, while the study group was treated with HFOV combined with PS. The therapeutic effects of the two groups were compared. Results After 6, 12, 24 hours of treatment, PaO2 increased significantly and PaCO2 decreased significantly in both groups, and those of the study group were better than the control group, and the differences were statistically significant(P<0.05). The OI values in the study group were significantly lower than those in the control group at 6, 12, 24 hours after treatment, and the differences were statistically significant(P <0.05). The stopping time of cerebral hemorrhage, oxygen exposure time,ventilation time and hospitalization time in the study group were significantly shorter than those in the control group, and the differences were statistically significant(P <0.05). The total incidence of complications in the study group was significantly lower than that in the control group, and the cure rate was significantly higher than that in the control group,the differences were statistically significant(P<0.05). Conclusion The combination of HFOV and PS in the treatment of NPH can effectively shorten the use time of ventilator and reduce the incidence of complications, which has higher safety and is worth learning.
CLINCAL RESEARCH AND PRACTICE
high-frequency oscillation ventilation
pulmonary hemorrhage of newborn