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粉末冶金制备的多孔Ti-10Mo合金用于促进骨修复的研究

Porous Ti-10Mo alloy fabricated by powder metallurgy for promoting bone regeneration
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摘要 本文中,我们以元素粉末为原料,采用粉末冶金造孔剂法制备了多孔Ti-10Mo合金,系统探讨了所制备的多孔Ti-10Mo合金的孔隙特征、显微组织、力学性能、体外生物相容性及体内骨整合能力.结果表明,随着造孔剂含量的增加(碳酸氢铵),在1300°C下烧结的多孔Ti-10Mo合金均由魏氏体组织组成.所制备的Ti-10Mo合金的孔隙率与平均孔尺寸能够分别控制在50.8%-66.9%与70.1-381.4μm.孔隙率为63.4%的Ti-10Mo合金具有最适合植入应用的力学性能,其弹性模量为2.9GPa,抗压屈服强度为127.5 MPa.在体外,Ti-10Mo合金浸提液对细胞增殖没有不良影响.细胞在浸提液中的存活率高于对照组,表明合金无毒性并且具有良好的生物学特征.在体内,植入8周后合金周围被新生骨包围,并且植入部分未见明显炎症.随着植入时间由2周增加到8周,多孔Ti-10Mo合金的骨结合强度从46.6N增加到176.4N.适合的力学性能以及良好的体外生物相容性和体内骨整合性使粉末冶金法制备的多孔Ti-10Mo成为一种具有吸引力的骨科植入合金. Porous Ti-lOMo alloys were fabricated by powder metallurgy using a space-holder method. The pore characteristics, m icrostructure, mechanical properties, in vitro biocompatibility, and in vivo osseointegration of the fabricated alloys were systematically investigated. The results show that with different weight ratios of the space-holder (NH4- HC03) added, all of the porous Ti-10Mo alloys sintered at 1,300℃ exhibited a typical W idmanstatten microstructure. The porosity and average pore size of the porous structures can be controlled in the range of 50.8%-66.9% and 70.1 -381.4μm , respectively. The Ti-10Mo alloy with 63.4% porosity exhibited the most suitable mechanical properties for implant applications with an elastic modulus of 2.9 GPa and a compressive yield strength of 127.5 MPa. In vitro9 the alloyconditioned medium showed no deleterious effect on the cell proliferation. The cell viability in this medium was higher than that of the reference group, suggesting non-toxicity and good biological characteristics of the alloy specimens. In vivo, after eight weeks* implantation, new bone tissue formed surrounding the alloy implants, and no noticeable inflammation was observed at the implantation site. The bone bonding strength of the porous Ti-10Mo alloy increased over time from 46.6N at two weeks to 176.4 N at eight weeks. Suitable mechanical properties together with excellent biocompatibility in vitro and osteointegration in vivo make the porous Ti-10Mo fabricated by powder metallurgy an attractive orthopedic implant alloy.
作者 徐伟 刘卓 路新 田静静 陈刚 刘博文 李舟 曲选辉 文翠娥 Wei Xu;Zhuo Liu;Xin Lu;Jingjing Tian;Gang Chen;Bowen Liu;Zhou Li;Xuanhui Qu;Cuie Wen(不详)
出处 《中国科学:材料科学(英文版)》 CSCD 2019年第7期1053-1064,共12页 Science China Materials
基金 Fundamental Research Funds for the Central Universities (FRF-GF-17-B39) Wen C acknowledges the financial support for this research by the National Health and Medical Research Council (NHMRC), Australia through project grant (GNT1087290).
关键词 粉末冶金法 合金 制备 骨修复 生物相容性 力学性能 孔隙特征 细胞增殖 porosity powder metallurgy structure characterization cell cytotoxicity osteointegration
作者简介 徐伟,These authors contributed equally.Wei Xu received his bachelor’s and master’s degree in materials science and engineering from Heilongjiang University of Science and Technology in 2014 and University of Science & Technology Beijing in 2017, respectively. Then he continued his study as a PhD candidate in Prof. Xuanhui Qu's and Xin Lu’s Lab in University of Science & Technology Beijing. His research interest mainly focuses on the biomedical metallic materials and near-net-shape process (selective laser sintering);刘卓,These authors contributed equally.Zhuo Liu is a PhD candidate in Beihang University, and he is also an exchange student in Beijing Institute of Nanoenergy and Nanosystems. His current research interest focuses on biomaterials, self-powered medical devices, and biomechanics;Corresponding author:路新,email: luxin@ustb.edu.cn,Xin Lu is a professor at Beijing Advanced Innovation Center for Materials Genome Engineering, Institute for Advanced Materials and Technology, University of Science and Technology Beijing. Her research interest mainly focuses on powder metallurgy of titanium-based alloy, including preparation and characteristics of alloy powders, titanium near-net-shape process (powder injection molding, selective laser sintering) and fast sintering techniques (spark plasma sintering), design and fabrication of new biomedical titanium alloys.
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