Porous Ti-lOMo alloys were fabricated by powder metallurgy using a space-holder method. The pore characteristics, m icrostructure, mechanical properties, in vitro biocompatibility, and in vivo osseointegration of the fabricated alloys were systematically investigated. The results show that with different weight ratios of the space-holder (NH4- HC03) added, all of the porous Ti-10Mo alloys sintered at 1,300℃ exhibited a typical W idmanstatten microstructure. The porosity and average pore size of the porous structures can be controlled in the range of 50.8%-66.9% and 70.1 -381.4μm , respectively. The Ti-10Mo alloy with 63.4% porosity exhibited the most suitable mechanical properties for implant applications with an elastic modulus of 2.9 GPa and a compressive yield strength of 127.5 MPa. In vitro9 the alloyconditioned medium showed no deleterious effect on the cell proliferation. The cell viability in this medium was higher than that of the reference group, suggesting non-toxicity and good biological characteristics of the alloy specimens. In vivo, after eight weeks* implantation, new bone tissue formed surrounding the alloy implants, and no noticeable inflammation was observed at the implantation site. The bone bonding strength of the porous Ti-10Mo alloy increased over time from 46.6N at two weeks to 176.4 N at eight weeks. Suitable mechanical properties together with excellent biocompatibility in vitro and osteointegration in vivo make the porous Ti-10Mo fabricated by powder metallurgy an attractive orthopedic implant alloy.
Fundamental Research Funds for the Central Universities (FRF-GF-17-B39)
Wen C acknowledges the financial support for this research by the National Health and Medical Research Council (NHMRC), Australia through project grant (GNT1087290).
徐伟,These authors contributed equally.Wei Xu received his bachelor’s and master’s degree in materials science and engineering from Heilongjiang University of Science and Technology in 2014 and University of Science & Technology Beijing in 2017, respectively. Then he continued his study as a PhD candidate in Prof. Xuanhui Qu's and Xin Lu’s Lab in University of Science & Technology Beijing. His research interest mainly focuses on the biomedical metallic materials and near-net-shape process (selective laser sintering);刘卓,These authors contributed equally.Zhuo Liu is a PhD candidate in Beihang University, and he is also an exchange student in Beijing Institute of Nanoenergy and Nanosystems. His current research interest focuses on biomaterials, self-powered medical devices, and biomechanics;Corresponding author:路新,email: email@example.com,Xin Lu is a professor at Beijing Advanced Innovation Center for Materials Genome Engineering, Institute for Advanced Materials and Technology, University of Science and Technology Beijing. Her research interest mainly focuses on powder metallurgy of titanium-based alloy, including preparation and characteristics of alloy powders, titanium near-net-shape process (powder injection molding, selective laser sintering) and fast sintering techniques (spark plasma sintering), design and fabrication of new biomedical titanium alloys.