Objective To compare the influence of Sodium Citrate anticoagulation and Low Molecular Weight Heparin Sodium on blood clotting, electrolyte, blood lipid and inflammation factor in patients with high-risk hemorrhage prone to continuous blood purification (CBP). Methods A total of 125 cases of critically ill patients treated with CBP in our hospital from January 2015 to March 2017 were collected and randomly divided into the observation group (65 cases) and the control group (60 cases) according to the time of admission. The observation group received Sodium Citrate anticoagulation, while the control group received Low Molecular Weight Heparin Sodium anticoagulation. The blood clotting, serum creatinine (SCr), blood urea nitrogen (BUN), electrolyte, blood lipid and inflammation factor were compared between the two groups. Results After treatment, the levels of SCr and BUN of the observation group were obviously lower than those of the control group, the life of filter in the observation group was significantly longer than that in the control group, and the activated partial clotting enzyme (APTT) in the observation group was shorter than that in the control group, there were significant differences (P<0.05). Conclusion Compared with Low Molecular Weight Heparin Sodium anticoagulation, Sodium Citrate anticoagulation group has little effect on coagulation index in high risk hemorrhage patients, which can reduce the level of SCr and BUN in peripheral blood of patients and prolong the service life of filters.
China Modern Medicine
Low Molecular Weight Heparin Sodium
Continuous blood purification