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自身免疫性脑炎患者体内NMDAR, CASPR和GABAbR在免疫球蛋白与激素联合治疗后的变化 预览

Changes of NMDAR, CASPR and GABAbR in patients with autoimmune encephalitis after combined immunoglobulin and hormone therapy
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摘要 探讨自身免疫性脑炎患者体内抗N-甲基-D-天冬氨酸受体(NMDAR)受体抗体脑炎、抗γ-氨基丁酸B受体(GABABR)抗体脑炎、抗接触蛋白相关蛋白样蛋白2(CASPR2)在免疫球蛋白与激素联合治疗后的变化研究。70例接受免疫球蛋白联合激素药物治疗的自身免疫性脑炎患者,检测药物治疗前后患者血清和脑脊液中NMDAR、CASPR2和GABABR的浓度变化进行比较分析。抗NMDAR脑炎患者血清和脑脊液NMDAR浓度显著下降;抗CASPR2脑炎患者血清和脑脊液CASPR2浓度显著下降;抗GABABR脑炎患者血清和脑脊液GABABR明显上升(P<0.05)。不同类型自身免疫性脑炎患者体内NMDAR,CASPR2和GABABR含量呈异常状态;临床应用免疫球蛋白与激素联合治疗可以有效缓解及治疗自身免疫性脑炎疾病。 To investigate the changes and significance of Anti-N-methyl-D-aspartate receptor (NMDAR) receptor antibody encephalitis, anti-gamma-aminobutyric acid B receptor (GABABR) antibody encephalitis, anti-contact protein-associated protein-like protein2 (CASPR2) in patients with different types of autoimmune encephalitis after combined treatment of immunoglobulin and hormones. 70 cases of patients with autoimmune encephalitis were treated with immunoglobulin and hormone therapy. The concentrations of NMDAR, CASPR2, and GABABR in serum and cerebrospinal fluid before and after drug treatment were compared and analyzed. Serum NMDAR concentrations in patients with anti-NMDAR encephalitis significantly decreased after treatment;CASPR2 concentrations in serum and cerebrospinal fluid of patients with anti-CASPR2 encephalitis decreased significantly;GABABR in serum and cerebrospinal fluid of patients with anti-GABABR encephalitis increased significantly ( P <0.05). The levels of NMDAR, CASPR2 and GABABR in patients with different types of autoimmune encephalitis are abnormal. The combination of clinical use of immunoglobulin and hormone can effectively relieve and treat autoimmune encephalitis diseases.
作者 谢柳青 谢敏 XIE Liuqing;XIE Min(Department of Neurology, Meishan People's Hospital,Meishan 620010, Sichuan, China;Department of Medicine, Chengdu 7th people's hospital, Chengdu 610045, Sichuan, China)
出处 《中南医学科学杂志》 CAS 2019年第2期173-176,共4页 Journal of Medical Sciencein Central Sauh China
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  • 1谢琰臣,许贤豪,张华,殷剑,刘银红,国红,矫毓娟,孟晓梅,冯凯,王红,许贤豪,张华,殷剑,刘银红,国红,矫毓娟,孟晓梅,冯凯,王红.以大剂量糖皮质激素冲击为主综合治疗重症肌无力的临床观察[J].中华神经科杂志,2006,39(8):511-515. 被引量:25
  • 2Dalmau J, Tuzun E, Wu HY, et al. Paraneoplastie anti-N-methyl-Daspartate receptor encephalitis associated with ovarian teratoma [ J ]. Ann Neurol,2007,61 ( 1 ) :25 -36. 被引量:1
  • 3Dalmau J,Gleichman A J, Hughes EG,et al. Anti-NMDA-receptor encephalitis:case series and analysis of the effects of antibodies [ J ]. Lancet Neuro1,2008,7 ( 12 ) : 1091 - 1098. 被引量:1
  • 4Iizuka T, Sakai F, Ide T, et al. Anti-NMDA receptor encephalitis in Japan:long-term outcome without tumor removal [ J ]. Neurology, 2008,70(7) :504 -511. 被引量:1
  • 5Florance NR, Davis RL, Lam C, et al. Anti-N-methyl-D-aspartate receptor(NMDAR) encephalitis in children and adolescents [ J ]. Ann Neurol,2009,66( 1 ) :11 - 18. 被引量:1
  • 6Irani SR,Vincent A. NMDA receptor antibody encephalitis[J]. Curr Neurol Neurosci Rep ,2011,11 ( 3 ) :298 - 304. 被引量:1
  • 7Varvat J, Lafond P, Page Y, et al. Acute psychiatric syndrome leading young patients to ICU : consider anti-NMDA-receptor antibodies [ J ]. Anaesth Intensive Care ,2010,38 (4) :748 - 750. 被引量:1
  • 8Pruss H, Dalmau J, Harms L, et al. Retrospective analysis of NMDA receptor antibodies in encephalitis of unknown origin [ J ]. Neurology, 2010,75(19) :1735 - 1739. 被引量:1
  • 9Davies G, Irani SR, Coltart C, et al. Anti-N-methyl-D-aspartate receptor antibodies:a potentially treatable cause of encephalitis in the intensive care unit[ J]. Crit Care Med ,2010,38 (2) :679 - 682. 被引量:1
  • 10Poloni C,Kor CM,Ricotti V,et al. Severe childhood encephalopathy with dyskinesia and prolonged cognitive disturbances: evidence for anti-N-methyl-d-aspartate encephalitis[J]. Dev Med Child Neurol, 2009,52(5 ) :78 - 82. 被引量:1

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