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不同时间窗服用安宫牛黄丸对中风病(脑出血)痰热证患者血清铁蛋白水平的影响 预览

Efficacy of Angong Niuhuang Wan on serum ferritin levels in patients with stroke (cerebral hemorrhage) of the Tanre syndrome in different time windows
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摘要 目的:观察不同时间窗服用安宫牛黄丸对中风病(脑出血)痰热证患者血清铁蛋白水平的影响。方法:选取于2015年10月-2018年3月广州市番禺区中医院收治的脑出血患者120例,采用随机数字表法分为治疗组和对照组(每60例),对照组给予内科常规治疗,治疗组在内科治疗的基础上口服安宫牛黄丸,并按首次给药时间不同分为3个亚组:<3h组(发病3h内给药)、3~6h组(发病3~6h给药)和6~12h组(发病6~12h给药),每组20例。并于治疗前及出血后3、7、14、90d抽取静脉血送检血清铁蛋白,评价不同组别之间血清铁蛋白水平的变化。结果:出血后3、7、14、90d治疗组血清铁蛋白水平均显著低于对照组(P<0.05)。治疗前<3h组、3~6h组、6~12h组血清铁蛋白水平对比差异无明显统计学意义(P>0.05),但随着给药时间延迟,血清铁蛋白水平均明显升高,在出血后3、7、14、90d三组差异均有统计学意义(P<0.05)。结论:安宫牛黄丸能有效降低脑出血患者血清铁蛋白水平,这可能是安宫牛黄丸的作用机理之一。 Objective:To observe efficacy of Angong Niuhuang Wan (安宫牛黄丸) on serum ferritin levels in patients with stroke (cerebral hemorrhage) of the Tanre syndrome (痰热证) in different time windows.Methods:120 cases were divided into two groups, 60 cases in each.The control group was given conventional treatment;and the treatment group was given Angong Niuhuang Wan.The treatment group was divided into 3 subgroups according to the time of the first administration,including <3 hours group (administered within 3 hours of onset),3 ~ 6 hours group (administered for 3 ~ 6 hours after onset) and 6 ~ 12 hours group (administered for 6 to 12 hours after onset),20 patients in each group.Serum ferritin levels were evaluated before treatment and at 3,7,14,and 90 days after hemorrhage.Results:At 3,7,14,and 90 days after hemorrhage,serum ferritin levels in the treatment group were significantly lower than those in the control group (P<0.05).Before treatment,there was no significant difference in serum ferritin levels between the <3 hours group,the 3~6 hours group,and the 6~12 hours group (P>0.05).With the delay of administration time,serum ferritin levels in each group were significantly increased,and the differences amage the three groups were statistically significant (P<0.05).Conclusion:Angong Niuhuang Wan on serum ferritin levels in patients with stroke (cerebral hemorrhage) of the Tanre syndrome shows a good effect.
作者 张用华 吴敏玲 Zhang Yonghua(不详)
出处 《中医临床研究》 2019年第11期83-85,共3页
基金 广州市医药卫生科技项目,项目编号:20152A011028。
关键词 脑出血 安宫牛黄丸 血清铁蛋白 时间窗 Cerebral hemorrhage Angong Niuhuang Wan Serum ferritin Time windows
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