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血清铁及铁蛋白与非小细胞肺癌TNM分期的相关性分析 预览

Correlation analysis of serum iron and ferritin with TNM staging in NSCLC
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摘要 目的铁代谢水平与非小细胞肺癌TNM分期的相关性分析。方法对我院2013年1月-2017年12月共计47例活检病理确诊为NSCLC的患者和41例肺炎患者进行铁代谢相关指标检测。结果NSCLC组血清铁及铁蛋白水平高于肺炎组(P<0.05)。且NSCLC组血清铁及铁蛋白与肿瘤TNM分期相关(P<0.05),铁蛋白与肿瘤的TNM分期是显著相关的(P<0.01)。结论NSCLC患者体内铁代谢可能参与了肿瘤的发生发展,针对铁代谢的治疗或许是NSCLC的一个新的治疗策略。 Objective To analyze the correlation between iron metabolism and TNM staging in non-small cell lung cancer(NSCLC).Methods A total of 47 patients with NSCLC confirmed by biopsy pathology and 41 patients with pneumonia in our hospital from January 2013 to December 2017 were tested for iron metabolism indicators.Results The levels of serum iron and ferritin in NSCLC patients were higher than those in pneumonia patients(P<0.05),and the levels of serum iron and ferritin in NSCLC patients were correlated with TNM staging of tumor(P<0.05),while ferritin was significantly correlated with TNM staging of tumor(P<0.01).Conclusion Iron metabolism in NSCLC patients may be involved in the occurrence and development of tumors,and treatment for iron metabolism may be a new strategy for NSCLC.
作者 张焕 许阳 夏雷鸣 汪毅 李红霞 鲍扬漪 ZHANG Huan;XU Yang;XIA Lei-ming;WANG Yi;LI Hong-xia;BAO Yang-yi(Department of Oncology,the Third People's Hospital Affiliated to Anhui Medical University,Hefei,Anhui230061,China)
出处 《临床肺科杂志》 2019年第6期1086-1090,共5页 Journal of Clinical Pulmonary Medicine
基金 合肥市卫健委应用医学研究重点项目(No.hwk2017zd013).
关键词 肺癌 血清铁 铁蛋白 TNM分期 lung cancer serum iron ferritin TMN staging
作者简介 通信作者:鲍扬漪,E-mail:761760565@qq.com.
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