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淫羊藿及其复方制剂治疗糖皮质激素性骨质疏松症的研究进展 预览

Advances in epimedium and its compound for the treatment of glucocorticoid-induced osteoporosis
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摘要 淫羊藿具有补肾壮阳、祛风除湿和强筋健骨的功效,主治腰酸腿痛、四肢拘挛、筋骨痿软等症。古人常用淫羊藿医治骨痿、骨痹、腰痛等疾病。现代医学也常将淫羊藿作为治疗各种类型骨质疏松症的中药之一。糖皮质激素常被用于治疗各种炎症、风湿及免疫相关疾病,随着临床医疗的普遍应用,其副作用也日益凸显,其中最严重的副作用之一就是会导致骨质疏松,即糖皮质激素性骨质疏松症。糖皮质激素性骨质疏松症是最常见的继发性骨质疏松症之一,仅居于老年性骨质疏松症和绝经后骨质疏松症之后,位于第三位。近年来对淫羊藿治疗骨质疏松症方面的研究日渐增多,大量医学研究表明淫羊藿在糖皮质激素性骨质疏松症的医治方面具有广阔的发展空间。本文通过查阅国内外相关文献,对目前淫羊藿治疗糖皮质激素性骨质疏松症作一文献综述,旨在为临床研究及实验研究奠定理论基础。 Epimedium herb has the functions of nourishing kidney and strengthening Yang, removing wind and dampness, strengthening muscle and strengthening bone. Epimedium herb is mainly used for the treatment of pain in the leg, spasm of limbs, physique impotent and so on. In ancient times, epimdium was commonly used to treat diseases such as impotence of bone, stuffiness of bone and backache. Epimedium is often used in modern medicine as one of the traditional Chinese medicines for the treatment of various types of osteoporosis. Glucocorticoid is commonly used to treat various inflammation, rheumatism and immune-related diseases. With the widespread application of glucocorticoid, its side effects are increasingly prominent. One of the most serious side effects is osteoporosis, namely glucocorticoid-induced osteoporosis(GIOP). Glucocorticoid-induced osteoporosis is one of the most common secondary osteoporosis, after senile osteoporosis and postmenopausal osteoporosis, it ranks the third. In recent years, more and more studies have been done on the effects of epimedium in the treatment of osteoporosis, a large number of medical studies have shown that epimedium has great potential in the treatment of glucocorticoid-induced osteoporosis. In this paper, by referring to relevant literature in domestic and abroad, we reviewed the treatment effect of epimedium in GIOP, aiming at laying the theoretical foundation for clinical research and experiment study.
作者 万亚宁 李双蕾 蒋云霞 陈文辉 贾慧敏 车日文 WAN Yaning;LI Shuanglei;JIANG Yunxia;CHEN Wenhui;JIA Huimin;CHE Riwen(Guangxi University of Traditional Chinese Medicine,Nanning 530001;The first Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)
出处 《中国骨质疏松杂志》 CAS CSCD 北大核心 2019年第5期713-716,共4页 Chinese Journal of Osteoporosis
基金 国家自然科学基金青年科学基金项目(81503403) 广西科技攻关计划课题(桂科攻14124004-1-26) 广西名老中医民族医传承工作室建设项目(桂卫中[2014]9号文件) 广西中医药大学青年基金项目(2016QN018).
关键词 骨质疏松 糖皮质激素 骨痹 淫羊藿 中医药 osteoporosis glucocorticoid osteoarthrosis epimedium traditional Chinese medicine
作者简介 通信作者:李双蕾,Email:Lslei66@126.com.
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