目的:探讨体外受精-胚胎移植中,不同冻融胚胎移植(frozen-thawed embryo transfer,FET)周期的妊娠结局。方法:选择2014-01~2016-01我院生殖医学中心行FET且年龄<40岁的女性为研究对象,共纳入374个FET周期。依据FET周期分为A组(1个周期)、B组(2个周期)和C组(≥3个周期)。对不同FET周期的妊娠结局进行回顾性分析。结果:A组的临床妊娠率、胚胎着床率、正常宫内妊娠率和抱婴率均显著高于B组、C组(P<0.01),但B组与C组比较差异不显著(P>0.05);A组的基础激素促黄体生成素(luteinizing hormone,LH)水平显著高于C组(P<0.01),而A组、C组与B组比较差异均不显著(P>0.05);C组的平均移植胚胎数显著高于A组(P<0.01),而A组、C组与B组比较差异均不显著(P>0.05)。结论:多次FET患者的临床妊娠率、胚胎着床率、正常宫内妊娠率和抱婴率均显著低于首次FET,但平均移植优质胚胎数无差异的情况下仍能获得同样的妊娠结局。
Objective:To investigate the pregnancy outcome of frozen-thawed embryo transfer(FET) cycles in vitro fertilization-embryo transfer(IVF).Methods:The female <40 years old undergoing FET cycle in our center from January 2014 to January 2016 were collected in this study.According to the FET cycles,a total of 374 FET cycles were divided into group A(one cycle),group B(two cycles) and group C(≥3 cycles).The pregnancy outcomes of FET cycles were analyzed retrospectively.Results:The implantation rate,clinical pregnancy rate,normal intrauterine pregnancy rate and live birth rate of group A were significantly higher than those of group B and group C(P<0.01),but there was no significant difference between group B and group C(P>0.05).Basis hormone luteinizing hormone(LH) levels of group A was significantly higher than that of group C(P<0.01),while both two groups have no significantdifference with group B(P>0.05).The average number of embryos transferred of group C was significantly higher than that of group A(P<0.01),while both two groups have no significant difference with group B(P>0.05).Conclusion:The clinical pregnancy rate,implantation rate,normal intrauterine pregnancy rate and live birth rate of repeatedly FET cycles are significantly lower than those of the first time.Whatever,embryo transfer cycles which have the same average number of high-quality embryos transferred can still obtain the same pregnancy outcomes.
Medical Journal of National Defending Forces in Northwest China
in vitro fertilization-embryo transfer
frozen-thawed embryos transfer