Objective: To analyze the clinical efficacy of entecavir (ETV) and adefovir dipivoxil(ADV) in the treatment of chronic hepatitis B (CHB). Methods: A total of 79 patients in our hospital from January 2011 to December 2015 were enrolled in this study,and randomly divided into ETV group ( n =44) and ADV group ( n =35).The liver and renal function indexes,creatine kinase (CK),the virological and serological response were observed after 48 weeks. Results: The serum levels of alanine aminotransferase (ALT),aspartate aminotransferase (AST),γ-glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP) in ETV group were evidently decreased after treatment,while the prealbumin (PA) content was increased ( P <0.05).The levels of serum ALT,AST and GGT after treatment in ADV group were notably decreased,whereas the CK content was increased ( P <0.05).No significant differences were found in the liver function indexes levels ( P >0.05).After treatment,the negative rate of HBV DNA in ETV group was significantly higher than that in ADV group ( P <0.05).There were no significant differences in the renal function and virological rebound rate between the two groups ( P >0.05). Conclusion: Both ETV and ADV were effective for the treatment of CHB,but ETV was superior to ADV in terms of antiviral effect and safety.
Journal of Guangxi Medical University