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Pm^2.5对儿童呼吸系统相关疾病的研究 预览

Study on Pm^2.5 in Children's Respiratory Related Diseases
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摘要 近年来,随着我国工业快速发展,能源的高消耗,空气污染问题已成为令人担忧的环境问题之一。雾霾现象日益严重,作为雾霾中最重要的致病物质-Pm^2.5的污染已成为我国一个严重的环境问题。其通过炎症反应、氧化应激、诱导自噬和细胞凋亡等方式引起呼吸系统疾病。儿童正处于生长发育期,属于Pm^2.5高度敏感的人群之一。Pm^2.5可随呼吸进入患儿气管甚至肺部,导致下呼吸道感染、哮喘、鼻炎、结核等呼吸系统发病率升高。但目前尚无很好的解决办法完全消除Pm^2.5造成的危害,未来还需要更多的研究进一步验证Pm^2.5的致病机制及其与儿童呼吸系统疾病的关系,并制订有效的预防措施和治疗方案。本文就Pm^2.5的来源及特征、致病机制及对儿童呼吸系统相关疾病的影响进行综述,旨在为临床研究提供参考。 In recent years, with the rapid development of China's industry and the high consumption of energy, air pollution has become one of the worrying environmental problems. The haze phenomenon has become increasingly serious, and the pollution of Pm^2.5, the most important pathogenic substance in smog, has become a serious environmental problem in China. Pm^2.5 causes respiratory diseases through inflammatory reactions, oxidative stress, induced autophagy, and apoptosis. The child is in the growth stage and is one of the highly sensitive people in Pm^2.5. Pm^2.5 can enter the child's trachea and even the lungs with breathing, leading to an increase in the incidence of respiratory diseases such as lower respiratory tract infections, asthma, rhinitis, and tuberculosis. However, there is no good solution to completely eliminate the harm caused by Pm^2.5. In the future, more research is needed to further verify the pathogenic mechanism of Pm^2.5 and its relationship with respiratory diseases in children, and to develop effective preventive measures. And treatment options. This article reviews the sources and characteristics of Pm^2.5, the pathogenesis and effects on children's respiratory related diseases, and aims to provide reference for clinical research.
作者 李昂 高一平 陈宇洲 孙燕燕 LI Ang;GAO Yi-ping;CHEN Yu-zhou;SUN Yan-yan(Department of Pharmacy,Tianjin Children's Hospital,Tianjin 300134,China;Department of Obstetrics,Tianjin Central Hospital of Obstetrics and Gynecology,Tianjin 300100, China;Department of Pharmacy,College of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)
出处 《医学信息》 2019年第11期29-35,共7页 Medical Information
关键词 Pm^2.5 来源及特征 致病机制 儿童 呼吸系统疾病 Pm^2.5 Source and characteristics Pathogenic mechanism Children Respiratory diseases
作者简介 李昂(1985.8-),男,天津人,硕士,主管药师,主要从事医院药学与药事管理的工作;通讯作者:孙燕燕(1968.7-),女,天津人,硕士,主任药师,主要从事临床用药与药事管理工作.
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