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ABCG2基因多态性与结直肠癌发生发展的相关性研究

Study on the correlation between the polymorphism of ABCG2 gene and the occurrence and progression of colorectal cancer
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摘要 目的探讨ABCG2基因rs2231137和rs2231142单核苷酸多态性(SNP)与结直肠癌发生发展的关系。方法选取2016年1月至2017年7月采用病例-对照研究,收集结直肠癌患者外周血样本690份,社区健康体检者外周血样本431份,使用TaqMan实时荧光定量PCR方法进行基因分型,应用χ^2检验和logistic回归进行ABCG2 rs2231137和rs2231142基因多态性与结直肠癌关联分析。结果对性别和年龄进行分层分析显示,携带ABCG2 rs2231142 AA基因型的男性,与CC基因型相比,结直肠癌发病风险降低(OR=0.50,95%CI:0.28~0.90,P=0.022)。年龄≤60岁携带rs2231137 AA基因型的结直肠癌患者发生Ⅰ、Ⅱ期肿瘤的比例高于Ⅲ、Ⅳ期(OR=0.29,95%CI:0.14~0.61,P=0.001)。结论 ABCG2 rs2231137和rs2231142单核苷酸多态性与结直肠癌的发生发展相关。 Objective The aim of the present study was to explore the correlation between the single nucleotide polymorphisms(SNP) of ABCG2 gene rs2231137 and rs2231142 and the occurrence and progression of colorectal cancer. Methods From January 2016 to July 2017, a case-control study was conducted to collect 690 peripheral blood samples from patients with colorectal cancer, and 431 peripheral blood samples from community healthy individuals.TaqMan real-time fluorescence quantitative PCR was used for genotyping.Chi-square test and logistic regression were used to analyze the association of ABCG2 rs2231137 and rs2231142 gene polymorphism with colorectal cancer. Results By stratified analysis of sex and age, it showed that men with the ABCG2 rs2231142 AA genotype had lower risk of colorectal cancer compared with the CC genotype(OR=0.50, 95%CI:0.28-0.90, P=0.022).The percentage of patients with stage Ⅰ and stage Ⅱ tumors was 0.293 times higher than those with stage Ⅲ and Ⅳ tumors among patients aged 60 years and older who carried rs2231137 AA genotype, suggesting a slower progression of tumor in those patients(OR=0.29, 95%CI:0.14-0.61, P=0.001). Conclusions Single nucleotide polymorphisms of rs2231137 and rs2231142 in ABCG2 gene were associated with the occurrence and development of colorectal cancer.
作者 张晓梅 孔晓玲 洪伟伟 张琰 武渊 程艳萍 杨圣 许思易 刘桐 梁戈玉 沈波 ZHANG Xiao-mei;KONG Xiao-ling;HONG Wei-wei;ZHANG Yan;WU Yuan;CHENG Yan-ping;YANG Sheng;XU Si-yi;LIU Tong;LIANG Ge-yu;SHEN Bo(Jiangsu Cancer Hospital,Jiangsu Institute of Cancer Research,Nanjing Medical University Affiliated Cancer Hospital,Nanjing,Jiangsu 210009,China)
出处 《中国预防医学杂志》 CAS CSCD 2019年第4期265-270,共6页 China Preventive Medicine
基金 国家自然科学基金资助项目(81673132) 江苏省科技项目(BE2O15719).
关键词 转运蛋白 ABCG2 单核苷酸多态性 结直肠癌 连锁不平衡 Transporter ABCG2 Single nucleotide polymorphism Colorectal cancer Linkage disequilibrium
作者简介 共同第一作者:张晓梅,硕士研究生,研究员,主要从事分子生物学研究;共同第一作者:孔晓玲,硕士研究生,主要从事单核昔酸多态性研究;通信作者:沈波,E-mail:shenbo987@126.com.
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